I-Triglyceride (TG) luhlobo lwamafutha anomxholo omkhulu emzimbeni womntu. Zonke izitho zomzimba kunye nezicubu zomzimba womntu zingasebenzisa i-triglyceride ukunika amandla, kwaye isibindi sinokuvelisa i-triglyceride size siyigcine esibindini. Ukuba i-triglyceride inyukile, oko kuthetha ukuba isibindi siqokelela amafutha amaninzi kakhulu, okuyi-fatty liver. I-Triglyceride luhlobo lwe-hyperlipidemia, kwaye eyona ngxaki yayo iphambili emzimbeni womntu kukubangela i-atherosclerosis, ukuvaleka kwemithambo yegazi kunye ne-thrombosis. Ukongeza, izifundo zibonise ukuba i-triglycerides ephezulu inokubangela uxinzelelo lwegazi, i-gallstones, i-pancreatitis, isifo se-Alzheimer kunye nokunye.
Uphando lweklinikhi olwenziwe kutshanje eJapan luphinde lwabonisa iingenelo ze-NMN emzimbeni womntu. Ngovavanyo lweklinikhi lomntu, iqela lophando libonakalise ukuba ukufakwa kwe-NMN ngemithambo kukhuselekile emzimbeni womntu, okungenakukwandisa kuphela amanqanaba e-NAD+ egazini, kodwa kunciphisa kakhulu amanqanaba e-triglyceride egazini ngaphandle kokonakalisa iiseli zegazi.
Iqela lophando liqeshe abantu abali-10 abasempilweni (amadoda ama-5 kunye nabasetyhini aba-5, abaneminyaka engama-20 ukuya kwengama-70 ubudala). Emva kokuzila ukutya iiyure ezili-12, i-300mg ye-NMN yanyibilikiswa kwi-100mL saline yaza yafakwa kubantu abazinikeleyo ngemithambo yengalo (5mL/min). Ii-X-ray zesifuba zathathwa ngaphambi nasemva kwenaliti ye-NMN, kwaye ubunzima, ubushushu, uxinzelelo lwegazi, ukubetha kwentliziyo kunye nokuqina kweoksijini yegazi kwalinganiswa. Igazi nomchamo zaqokelelwa ukuze kuvavanywe. Ngohlalutyo oluthelekisayo lweziphumo zovavanyo, kufunyaniswe ukuba iimpawu eziphambili zesibindi, i-pancreas, intliziyo kunye nezintso azinatshintsho lucacileyo, kwaye ukongeza, aziyi kuchaphazela iimpawu eziphambili zeeseli ezibomvu zegazi, iiseli ezimhlophe zegazi kunye neeplatelets egazini, kwaye abathathi-nxaxheba abanazo iziphumo ezimbi.
Kubalulekile ukuqaphela ukuba inqanaba le-triglyceride egazini litshintshile ngokucacileyo. Emva kokuba abantu befumene inaliti ye-NMN kangangesiqingatha seyure, inqanaba le-triglyceride lehla ngokucacileyo, de kwaba ziiyure ezi-5 kamva, nangona kwakukho umkhwa omncinci wokuchacha, lo mahluko ubalulekileyo wawusekho.
Ukususela kwizilingo zangaphambi kokuhlolwa kwezilwanyana ukuya kwizilingo zeklinikhi zabantu, iingenelo ze-NMN emzimbeni womntu ziqinisekisiwe ngempumelelo. Olu phononongo lweklinikhi lwabantu lungqina umsebenzi we-NMN ekunciphiseni i-triglyceride, nto leyo eyindaba ezimnandi kubantu abatyebileyo nabalupheleyo.
Iireferensi:
[1]. UKimura S, uIchikawa M, uSugawara S, nabanye. (nge-05 kaSeptemba 2022) I-Nicotinamide Mononucleotide inyibilikiswa ngokukhuselekileyo kwaye inciphisa kakhulu amanqanaba e-Triglyceride egazini kubantu abaphilileyo. I-Cureus 14(9): e28812. doi:10.7759/cureus.28812
Ixesha lokuthumela: Novemba-11-2022