Uphononongo lweklinikhi kumzimba womntu: I-NMN inokunciphisa ngokufanelekileyo inqanaba le-triglyceride

I-Triglyceride (TG) luhlobo lwamafutha olunomxholo omkhulu kumzimba womntu.Zonke izitho kunye nezicubu zomzimba womntu zingasebenzisa i-triglyceride ukunika amandla, kwaye isibindi sinokudibanisa i-triglyceride kwaye siyigcine esibindi.Ukuba i-triglyceride yonyuswa, ithetha ukuba isibindi siqokelela amanqatha amaninzi, isibindi esinamafutha.I-Triglyceride luhlobo lwe-hyperlipidemia, kwaye eyona nto iyingozi kumzimba womntu kukubangela i-atherosclerosis, ukuvaleka kwemithambo yegazi kunye ne-thrombosis.Ukongeza, uphando lubonise ukuba i-triglycerides ephezulu inokubangela uxinzelelo lwegazi, i-gallstones, i-pancreatitis, isifo se-Alzheimer kunye nokunye.

Uphononongo lwamva nje lweklinikhi yabantu eJapan luphinde lwangqina izibonelelo ze-NMN kumzimba womntu.Ngovavanyo lweklinikhi yabantu, iqela lophando libonakalise ukuba inaliti ye-NMN ikhuselekile kumzimba womntu, engenako ukunyusa kakhulu kuphela inqanaba le-NAD+ legazi, kodwa ikwanciphisa kakhulu inqanaba le-triglyceride yegazi ngaphandle kokonakalisa iiseli zegazi.

Iqela lophando lifumene amavolontiya anempilo e-10 (amadoda ama-5 kunye nabasetyhini aba-5, abaneminyaka eyi-20 ~ 70 iminyaka).Emva kokuzila ukutya kwiiyure ze-12, i-300mg ye-NMN yachithwa kwi-saline ye-100mL kwaye ifakwe kumavolontiya nge-arm vein (5mL / min).I-X-rays yesifuba yathathwa ngaphambi nangemva kwe-NMN injection, kunye nobunzima, ukushisa, uxinzelelo lwegazi, i-pulse kunye ne-blood saturation saturation.Igazi kunye nomchamo zaqokelelwa ukuze zihlolwe.Ngokusebenzisa uhlalutyo lokuthelekisa inani leziphumo zovavanyo, kufunyaniswe ukuba awona maphawu aphambili esibindi, i-pancreas, intliziyo kunye nezintso azikho utshintsho olucacileyo, kwaye ukongeza, aziyi kuchaphazela iimpawu eziphambili zeeseli ezibomvu zegazi, iiseli ezimhlophe zegazi. kunye neeplatelet egazini, kwaye abathathi-nxaxheba abanazo iziphumo ezibi.

Kuyafaneleka ukuba uqaphele ukuba izinga le-triglyceride egazini litshintshile ngokucacileyo.Emva kokuba izifundo zifumene i-NMN i-injection yesiqingatha seyure, inqanaba le-triglyceride lehla ngokucacileyo, kude kube ziiyure ze-5 kamva, nangona kwakukho umkhwa omncinci wokubuyisela, lo mahluko obalulekileyo usekho.

Ukusuka kwiimvavanyo zezilwanyana zangaphambi kweklinikhi ukuya kuvavanyo lweklinikhi yabantu, izibonelelo ze-NMN kumzimba womntu ziye zaqinisekiswa ngokufanelekileyo.Olu phononongo lweklinikhi lomntu lubonisa umsebenzi we-NMN ekunciphiseni i-triglyceride, iindaba ezilungileyo kubantu abatyebileyo nabakhulileyo.

IiReferensi:
[1].Kimura S, Ichikawa M, Sugawara S, et al.(NgoSeptemba 05, 2022) I-Nicotinamide Mononucleotide iSetyenziswe ngokuKhuselekileyo kwaye iNciphisa ngokuphawulekayo amaNqanaba eGazi le-Triglyceride kubantu abasempilweni.Cureus 14(9): e28812.doi:10.7759/cureus.28812