Kwiminyaka yakutshanje, ngokunyuka kwendlela yokuphila engafanelekanga kunye nokunyuka koxinzelelo lwentlalo yabasetyhini, izinga lokunyuka kwe-polycystic ovary syndrome (PCOS) liye lacaca ngakumbi.Izifundo zangaphandle zibonise ukuba iziganeko ze-polycystic ovary syndrome (PCOS) kubasetyhini abaneminyaka yobudala yokuzala ziphezulu njenge-6% -15%, ngelixa e-China, umlinganiselo uphezulu njenge-6% -10%.
I-Polycystic ovary syndrome sisifo esihlala sivela kubasetyhini abaneminyaka yobudala ngenxa yokuphazamiseka kwe-endocrine.Ibonakaliswa ikakhulu kwi-glucose engaqhelekanga kunye ne-lipid metabolism kunye nokungasebenzi kakuhle kokuzala.Iikhrayitheriya zokuxilongwa kweklinikhi kukuphazamiseka kwenqanaba lehomoni (i-androgen ephezulu), i-dilute ukuphazamiseka kwe-Ovulation kunye notshintsho lwe-ovarian polycystic, kwaye uninzi lwabasetyhini abane-PC COS baneempawu ezimbi ze-metabolic, ezifana nokunganyangeki kwe-insulin, ukutyeba, kunye ne-hepatic steatosis.
Okwangoku, kukho amachiza ambalwa onyango lwe-PCOS.Indlela eqhelekileyo kukuphucula i-PCOS ngokujolisa kunye nokuthintela ukugqithisa kwe-androgen kunye neziyobisi ezichasene ne-androgen.Nangona kunjalo, kukho ubungqina bokuba iziyobisi ezichasayo ze-androgen zinetyhefu enamandla yesibindi, ngoko ke ukusetyenziswa kwazo kulinganiselwe.Ngoko ke, kubaluleke kakhulu ukufuna into yendalo ngaphandle kwemiphumo emibi yokutshintsha iziyobisi zangoku.
uphando olutshanje lweYunivesithi yaseNew South Wales e-Australia yafumanisa ukuba i-polycystic ovary syndrome inxulumene nokusilela kwe-NAD +, kwaye iziphumo zophando zapapashwa kwiphephancwadi lesayensi elithi "Molecular Metabolism" .
Iqela lophando laqala ukufaka i-dihydrotestosterone (DHT) ngaphantsi kweempuku zabasetyhini ngaphambi nangemva kokufikisa ukuseka imodeli yemouse ye-PC COS, kwaye emva kweeveki ze-8 zonyango lwe-NMN, i-insulin yokuzila kunye ne-HOMA yokufumanisa ukuxhathisa kwe-insulin, uvavanyo lokunyamezela i-glucose, amafutha Emva kovavanyo olunjalo. njenge-histomorphometry, iziphumo zobalo zibonisa:
1. I-N MN ibuyisela i-N AD + inqanaba kwi-muscle ye-PS COS iigundane
yafumanisa ukuba inqanaba le-NAD + kwi-muscle yeegundane ze-PCOS liye lancipha kakhulu, kwaye inqanaba le-NAD kwi-muscle ye-PCOS yeegundane libuyiselwe ngokutya kwe-NMN.
2. I-NMN iphucula ukuxhathisa kwe-insulin kunye nokukhuluphala kwiigundane ze-PCOS
Amanqanaba e-insulin enziwe yi-DHT ngaphezulu kokuphindwe kabini kwiimpuku ze-PCOS ezizila ukutya, mhlawumbi ebonisa ukuxhathisa kwe-insulin.Ngokutyisa i-NMN, kwafunyaniswa ukuba inqanaba le-insulin yokuzila libuyiselwe kwinqanaba elikufutshane nelo leempuku eziqhelekileyo.Ukongeza, ubunzima bomzimba weempuku ze-PCOS bunyuke nge-20%, kwaye ubunzima bamafutha bunyuke kakhulu.
3. I-NMN ibuyisela i-hepatic lipid deposition engaqhelekanga kwiigundane ze-PCOS
Enye yeempawu ze-polycystic ovary syndrome yi-lipid deposition kwisibindi kunye nokufakwa kwesibindi esinamafutha.Emva kokuthatha i-NMN, i-lipid deposition engaqhelekanga kwimicebe ye-PCOS yayiphantse yapheliswa, kwaye i-triglycerides esibindi ibuyele kwinqanaba leempuku eziqhelekileyo.
ukuqukumbela, inqanaba le-NAD + kwi-muscle ye-PCOS yancitshiswa kakhulu, kwaye imeko ye-PCOS yancitshiswa ngokuncedisa i-NMN, i-precursor ye-NAD +, enokuba sisicwangciso sonyango sonyango lwe-PCOS.
iimbekiselo:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Ukuncipha kwemisipha ye-NAD + kwi-hyperandrogenism ye-PCOS imodeli yegundane: Indima enokwenzeka kwi-metabolic dysregulation.Mol Metab.2022 Sep 9;65:101583.doi: 10.1016/j.molmet.2022.101583.Epub phambi koshicilelo.PMID: 36096453.
Ixesha lokuposa: Nov-17-2022