Kwiminyaka yakutshanje, ngenxa yokwanda kwendlela yokuphila engeyiyo impilo kunye noxinzelelo olukhulayo lwabasetyhini, izinga lokuxhaphaka kwe-polycystic ovary syndrome (PCOS) liye lacaca ngakumbi nangakumbi. Izifundo zangaphandle zibonise ukuba ukuxhaphaka kwe-polycystic ovary syndrome (PCOS) kwabasetyhini abakwiminyaka yokuzala kuphezulu ukuya kuthi ga kwi-6% -15%, ngelixa eTshayina, inani liphezulu ukuya kuthi ga kwi-6% -10%.
I-Polycystic ovary syndrome sisifo esidla ngokuvela kubafazi abakwiminyaka yokuzala ngenxa yeengxaki ze-endocrine. Ibonakala kakhulu kwi-glucose engaqhelekanga kunye ne-lipid metabolism kunye nokungasebenzi kakuhle kokuzala. Iimpawu zokuxilonga zeklinikhi kukuphazamiseka kwenqanaba le-hormone (i-androgen ephezulu), ukuphazamiseka kwe-Ovulation kunye notshintsho lwe-ovarian polycystic, kwaye uninzi lwabasetyhini abane-PC COS baneempawu ezimbi ze-metabolic, ezinje ngokuxhathisa i-insulin, ukutyeba kakhulu, kunye ne-hepatic steatosis.
Okwangoku, zimbalwa iziyobisi zonyango lwe-PCOS. Indlela eqhelekileyo kukuphucula i-PCOS ngokujolisa nokuthintela ubuninzi be-androgen ngamayeza alwa ne-androgen. Nangona kunjalo, kukho ubungqina bokuba amayeza alwa ne-androgen anetyhefu yesibindi, ngoko ke ukusetyenziswa kwawo kulinganiselwe. Ke ngoko, kubaluleke kakhulu ukufuna into yendalo engenazo iziphumo ebezingalindelekanga ukuze ithathe indawo yamayeza akhoyo.
Uphononongo lwakutshanje olwenziwe yiYunivesithi yaseNew South Wales eOstreliya lufumanise ukuba i-polycystic ovary syndrome inxulumene nokunqongophala kwe-NAD+, kwaye iziphumo zophando zipapashwe kwijenali yesayensi ethi "Molecular Metabolism".
Iqela lophando laqala ngokufaka i-dihydrotestosterone (DHT) phantsi kwesikhumba kwiimpuku zabasetyhini ngaphambi nasemva kokufikisa ukuze kusekwe imodeli yegundane ye-PC COS, emva koko emva kweeveki ezi-8 zonyango lwe-NMN, i-insulin yokuzila ukutya kunye nokufunyanwa kwe-insulin ye-HOMA, uvavanyo lokunyamezela i-glucose, amafutha Emva kovavanyo olufana ne-histomorphometry, iziphumo zezibalo zibonisa:
1. I-N MN ibuyisela inqanaba le-N AD + kwizihlunu zeempuku ze-P COS
bafumanise ukuba inqanaba le-NAD+ kwimisipha yeempuku ze-PCOS lehle kakhulu, kwaye inqanaba le-NAD kwimisipha yeempuku ze-PCOS labuyiselwa ngokutya i-NMN.
2. I-NMN iphucula ukuxhathisa i-insulin kunye nokutyeba kakhulu kwiimpuku ze-PCOS
Amanqanaba e-insulin abangelwa yi-DHT aphindwe kabini kwiimpuku ze-PCOS ezizila ukutya, mhlawumbi ebonisa ukunganyangeki kwe-insulin. Ngokutyisa i-NMN, kwafunyaniswa ukuba inqanaba le-insulin yokuzila ukutya labuyiselwa kwinqanaba elikufutshane neleempuku eziqhelekileyo. Ukongeza, ubunzima bomzimba weempuku ze-PCOS bunyuke ngama-20%, kwaye ubunzima bamafutha banda kakhulu.
3. I-NMN ibuyisela ukugcinwa kwamafutha esibindini okungaqhelekanga kwiimpuku ze-PCOS
Enye yeempawu ze-polycystic ovary syndrome kukufakwa kwe-lipid esibindini kunye nokungeniswa kwesibindi esinamafutha. Emva kokuthatha i-NMN, ukufakwa kwe-lipid esibindini okungaqhelekanga kwiimpuku ze-PCOS kwaphantse kwaphela, kwaye i-triglycerides esibindini yabuyela kwinqanaba leempuku eziqhelekileyo.
Isiphelo, inqanaba le-NAD+ kwimisipha ye-PCOS lancitshiswa kakhulu, kwaye imeko ye-PCOS yancitshiswa ngokongeza i-NMN, eyandulela i-NAD+, enokuba yindlela yonyango enokubakho yonyango lwe-PCOS.
iireferensi:
[1]. Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Ukwehla kwemisipha ye-NAD+ kwimodeli yegundane ye-PCOS ene-hyperandrogenism: Indima enokwenzeka kwi-metabolic dysregulation. Mol Metab. 2022 Sep 9;65:101583. doi: 10.1016/j.molmet.2022.101583. I-Epub ngaphambi kokushicilelwa. PMID: 36096453.
Ixesha lokuthumela: Novemba-17-2022