I-NMN inciphisa i-intestinal fibrosis ebangelwa yimitha ngokuguqula i-gut microbiota

I-radiation-induced intestinal fibrosis yingxaki eqhelekileyo kubantu abasinde ixesha elide emva konyango lwe-radiation esiswini nakwi-pelvic. Okwangoku, akukho ndlela ifumanekayo yeklinikhi yokunyanga i-radiation-induced intestinal fibrosis. Izifundo zibonise ukuba i-nicotinamide mononucleotide (NMN) inako ukulawula i-intestinal flora. I-intestinal flora yi-microorganism eqhelekileyo emathunjini omntu, enokuvelisa izakhamzimba ezahlukeneyo ezifunekayo ekukhuleni nasekuphuhliseni komntu. Xa i-intestinal flora ingalingani, iya kubangela izifo ezahlukeneyo.
Kutshanje, i-China Academy of Medical Sciences kunye nePeking Union Medical College zipapashe iziphumo zophando kwijenali i-International Journal of Radiation Biology, ezibonise ukuba i-NMN inokunciphisa i-intestinal fibrosis ebangelwa yimitha ngokulawula izityalo zamathumbu.
Ekuqaleni, iqela lophando lahlulahlula iimpuku zibe liqela lolawulo, iqela le-NMN, iqela le-IR kunye neqela le-NMNIR, kwaye lanika imitha ye-15 Gy esiswini kwiqela le-IR kunye neqela le-NMNIR. Okwangoku, isongezelelo se-NMN sanikwa iqela le-NMN kunye neqela le-NMNIR ngedosi yemihla ngemihla ye-300mg/kg. Emva kokuyithatha ixesha elithile, ngokubona ilindle leempuku, i-microflora yamathumbu kunye neempawu zezicubu zamathumbu, iziphumo zokuthelekisa zabonisa ukuba:

1. I-NMN inokulungisa ukwakheka kunye nomsebenzi wezityalo zamathumbu eziphazamiseka yimitha.
Ngokuthelekisa ukufunyanwa kwezityalo zamathumbu phakathi kweqela le-IR kunye neqela le-NMNIR, kwafunyaniswa ukuba iimpuku zeqela le-IR zonyusa ubuninzi bezityalo zamathumbu eziyingozi, ezifana neLactobacillus du, iBacillus faecalis, njl. Okumangalisayo kukuba, iimpuku zeqela le-NMNIR zitshintshe ulwahlulo lwezityalo zamathumbu zaza zonyusa ubuninzi bezityalo zamathumbu eziluncedo, ezifana nebhaktheriya ye-AKK, ​​ngokongeza i-NMN. Uvavanyo lubonisa ukuba i-NMN inokulungisa ukwakheka kunye nomsebenzi wezityalo zamathumbu ongekho semgangathweni ngenxa yemitha.

2. I-NMN iyanciphisa i-fibrosis yamathumbu ebangelwa yimitha
Inqanaba le-aSMA (Fibrosis Marker) kwiimpuku ezichaphazeleke kwimitha yelanga landa kakhulu. Emva kokongezwa kwe-NMN, ayilonqanaba le-aSMA marker kuphela eliye lehla kakhulu, kodwa ne-inflammatory factor TGF-b eyayikhuthaza i-intestinal fibrosis yehla kakhulu, nto leyo ebonisa ukuba ukongezwa kwe-NMN kunokunciphisa i-intestinal fibrosis ebangelwa yimitha yelanga.

(Umfanekiso 1. Unyango lwe-NMN lunciphisa i-intestinal fibrosis ebangelwa yimitha)

Ngenxa yokuxhaphaka kweemveliso ze-elektroniki, imitha yelanga inempembelelo eyandayo kumsebenzi nakubomi babantu, ingakumbi kwiintyatyambo zamathumbu ixesha elide. I-NMN inempembelelo enamandla yokukhusela impilo yamathumbu. Esi siphumo asipheleli nje kwinto enye okanye kwindlela ethile, kodwa sikwalawula ulwakhiwo losasazo lwezityalo ukukhuthaza uzinzo lomsebenzi wamathumbu ukusuka kwiikona ezahlukeneyo kunye neendlela, nto leyo ekwabonelela ngereferensi ebalulekileyo yeenzuzo ezahlukeneyo ze-NMN.

Iireferensi:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): I-NMN inciphisa i-radiation-induced intestinal fibrosis ngokumodareyitha i-gut microbiota, i-International Journal ye-Radiation Biology, i-DOI: 10.10502029292.