I-NMN inciphisa i-radiation-induced intestinal fibrosis ngokumodareyitha i-gut microbiota

I-radiation-induced intestinal fibrosis yingxaki eqhelekileyo yabantu abasindileyo ixesha elide emva kwe-radiotherapy yesisu kunye ne-pelvic.Okwangoku, akukho ndlela ifumanekayo ekliniki yokunyanga i-radiation-induced intestinal fibrosis.Uphononongo lubonise ukuba i-nicotinamide mononucleotide (NMN) inamandla okulawula iintyatyambo zamathumbu.I-Intestinal flora yi-microorganism eqhelekileyo emathunjini omntu, enokuthi idibanise iindidi zezondlo eziyimfuneko ekukhuleni nasekuphuhliseni komntu.Emva kokuba i-intestinal flora ingalingani, iya kubangela izifo ezahlukahlukeneyo.
Kutshanje, i-China Academy yeSayensi yezoNyango kunye nePeking Union Medical College ipapashe iziphumo zophando kwijenali ye-International Journal yeRadiation Biology, ebonisa ukuba i-NMN inokunciphisa i-intestinal fibrosis ebangelwa yimitha ngokulawula iintyatyambo zamathumbu.
Ekuqaleni, iqela lophando lahlula iigundane kwiqela lolawulo, iqela le-NMN, iqela le-IR kunye neqela le-NMNIR, kwaye wanika i-15 Gy irradiation yesisu kwiqela le-IR kunye neqela le-NMNIR.Ngeli xesha, isongezelelo se-NMN sanikezelwa kwiqela le-NMN kunye neqela le-NMNIR kwidosi yemihla ngemihla ye-300mg/kg.Emva kokuyithatha ixesha elithile, ngokufumanisa ilindle lempuku, i-intestinal microflora kunye ne-colon tissue markers, iziphumo zokuthelekisa zibonise ukuba:

1. I-NMN inokulungisa ukubunjwa kunye nomsebenzi we-intestinal flora ephazanyiswa yimitha.
Ngokuthelekisa ukufunyanwa kweentyantyambo zamathumbu phakathi kweqela le-IR kunye neqela le-NMNIR, kwafunyaniswa ukuba iigundane zeqela le-IR zonyusa ubuninzi bezityalo ezinobungozi zamathumbu, ezifana neLactobacillus du, i-Bacillus faecalis, njl. Okumangalisayo kukuba, iigundane zeqela le-NMNIR zitshintshe ukuhlukahluka kwamathumbu emathunjini. kunye nokwandisa ubuninzi bezityalo zamathumbu ezixhamlayo, ezifana neebhaktheriya ze-AKK, ​​ngokuncedisa i-NMN.Iimvavanyo zibonisa ukuba i-NMN inokulungisa ukubunjwa kunye nokusebenza kweentyantyambo zamathumbu eziphuma kwi-balancer ngenxa yemitha.

2. I-NMN inciphisa i-intestinal fibrosis ebangelwa yimitha
Inqanaba le-aSMA (i-Fibrosis Marker) kwiimpuku ezivezwe kwimitha yemitha landa kakhulu.Emva kokuxhaswa kwe-NMN, kungekhona kuphela inqanaba le-asMA marker lehla kakhulu, kodwa kunye ne-inflammation factor TGF-b eyakhuthaza i-intestinal fibrosis yehla kakhulu, ebonisa ukuba ukuxhaswa kwe-NMN kunokunciphisa i-intestinal fibrosis ebangelwa yimitha.

(Umfanekiso 1. unyango lwe-NMN lunciphisa i-intestinal fibrosis ebangelwa yi-radiation)

Ngaphantsi kwemvelaphi yokuxhaphaka kweemveliso ze-elektroniki, i-radiation inefuthe elikhulayo kumsebenzi kunye nobomi babantu, ngakumbi kwi-intestinal flora ixesha elide.I-NMN inefuthe elinamandla lokukhusela kwimpilo yamathumbu.Esi siphumo asifezekanga kuphela ngento enye okanye indlela ethile, kodwa kwakhona ngokulawula isakhiwo sokusasazwa kweentyatyambo ukukhuthaza ukuzinza komsebenzi wamathumbu ukusuka kwii-angles ezahlukeneyo kunye nezalathiso, ekwabonelela ngesalathiso esibalulekileyo kwiinzuzo ezahlukeneyo ze-NMN.

IiReferensi:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): I-NMN inciphisa i-radiation-induced intestinal fibrosis ngokumodareyitha i-gut microbiota, i-International Journal ye-Radiation Biology, i-DOI: 10.10502029292.