I-Hypopigmentation sisifo solusu, esibonakaliswa kakhulu kukunciphisa i-melanin. Iimpawu eziqhelekileyo ziquka i-vitiligo, i-albinism kunye ne-hypopigmentation emva kokudumba kolusu. Okwangoku, unyango oluphambili lwe-hypopigmentation lunyango lomlomo, kodwa unyango lomlomo luya kubangela ukubola kolusu, ukungonwabi kwesisu kunye nezinye iziphumo ebezingalindelekanga. Ke ngoko, kuyimfuneko ukuphuhlisa into yendalo engenazo iziphumo ebezingalindelekanga ukunyanga i-hypopigmentation.
Kutshanje, iScientific Reports ipapashe inqaku elinesihloko esithi "Uphando olucwangcisiweyo lubonisa amandla e-spermidine onyango lwe-hypopigmentation |ngokuzinzisa iiproteni ezinxulumene ne-melanogenesis". Iziphumo zibonisa ukuba i-spermidine inokunyangwa ngokuzinzisa iiproteni ezinxulumene ne-melanogenesis.
Unyango lweSpermidine lonyusa ukuveliswa kwe-melanin
Ukuze kufundwe impembelelo ye-spermidine kwimveliso ye-melanin, iqela lophando linyange i-melanin kwiiseli ze-MNT-1 ngamanqanaba ahlukeneyo e-spermidine. Ngohlalutyo lobungakanani, kwafunyaniswa ukuba unyango lwe-spermidine lwandisa imveliso ye-melanin.
I-Spermidine inokulawula inkqubo yokuwohloka kweproteni enxulumene ne-melanogenesis
Ukuze kuqinisekiswe ukuba i-spermidine iyakwazi ukulawula ii-genes ezibandakanyeka ekonakaleni kweproteni, iqela lophando lifumanise ii-genes ezili-181 ezilawulwa phantsi kwaye ii-genes ezingama-82 zilawulwa ngokufumana iiseli eziphathwe yi-spermidine ngendlela ecwangcisiweyo, ngaphandle kwee-genes ezinxulumene ne-melanogenesis. Ukuqinisekisa ngakumbi, iqela lophando lihlalutye impembelelo ye-spermidine kwinqanaba lokubonakaliswa kosapho lwe-tyrosinase gene i-TYR, i-TRP-1 kunye ne-TRP-2, ezizii-genes ezilawula ngokusondeleyo ukuveliswa kwe-melanin. Inqanaba lokubonakaliswa kwe-mRNA liqinisekisile ukuba i-spermidine ayitshintshanga ukubonakaliswa kwee-genes ezinxulumene ne-melanogenesis. Nangona kunjalo, umsebenzi wee-genes ezininzi utshintshwa yi-spermidine kwaye unxulumene nokonakala kweproteni. Ii-genes ezininzi ezitshintshiweyo zinxulumene nobuninzi, oluyinkqubo yokonakala kweproteni enxulumene ne-melanogenesis.
I-Spermidine ilawula uzinzo lweeproteni kwaye ikhuthaza ukuveliswa kwe-melanin.
Ukuveliswa kwe-melanin kulawulwa kukulinganisela kokwenziwa kunye nokuwohloka kweeproteni ezinxulumene ne-melanin. I-Spermidine iphatha ii-gene ze-TYR, TRP-1 kunye ne-TRP-2. Ngokusebenza kwee-genes zokuthutha i-SLC3A2, SLC7A1, SLC18B1 kunye ne-SLC22A18, inokunyusa izinga le-polyamines kwiiseli, ngaloo ndlela inyusa uzinzo lweeproteni ezinxulumene nokuveliswa kwe-melanin ukukhuthaza ukuveliswa kwe-melanin emzimbeni.
Ukuqukumbela, olu phononongo lubonisa ukuba i-spermidine yendalo inendima enokubakho kunyango lwe-hypopigmentation, kwaye inexabiso elithile lokusetyenziswa kwicandelo lezinto zokuthambisa kunye neemveliso zempilo kwixesha elizayo.
Isalathiso:
[1].Brito, S., Heo, H., Cha, B. et al. Uphando olucwangcisiweyo lubonisa amandla e-spermidine kunyango lwe-hypopigmentation ngokuzinzisa iiproteni ezinxulumene ne-melanogenesis. Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Ixesha lokuthumela: Sep-28-2022