I-Hypopigmentation sisifo solusu, esibonakaliswa ikakhulu ngokunciphisa i-melanin.Iimpawu eziqhelekileyo ziquka i-vitiligo, i-albinism kunye ne-hypopigmentation emva kokuvuvukala kwesikhumba.Okwangoku, unyango oluphambili lwe-hypopigmentation lunyango lomlomo, kodwa iyeza lomlomo liya kubangela i-atrophy yesikhumba, ukuphazamiseka kwesisu kunye nezinye iziphumo ezibi.Ngoko ke, kuyimfuneko ukuphuhlisa into yendalo ngaphandle kwemiphumo emibi ukunyanga i-hypopigmentation.
Kungekudala, iiNgxelo zeNzululwazi zipapashe inqaku elinesihloko esithi "Ukuhlola okucwangcisiweyo kubonisa amandla e-spermidine yonyango lwe-hypopigmentation | ngokuzinzisa iiprotheni ezinxulumene ne-melanogenesis".Iziphumo zibonisa ukuba i-spermidine inokunyangwa ngokuzinzisa iiprotheni ezinxulumene ne-melanogenesis.hypopigmentation.
一、Spermidine unyango kwandisa imveliso melanin
Ukuze ufunde umphumo we-spermidine kwimveliso ye-melanin, iqela lophando liye laphatha i-melanin kwiiseli ze-MNT-1 ezinemilinganiselo eyahlukeneyo ye-spermidine.Ngokusebenzisa uhlalutyo lobungakanani, kwafunyaniswa ukuba unyango lwe-spermidine lwandise ukuveliswa kwe-melanin.
I-Spermidine inokulawula inkqubo yokuthotywa kweprotheni ehambelana ne-melanogenesis
Ukuze kuqinisekiswe ukuba i-spermidine inokulawula iijene ezibandakanyekayo ekuthotyweni kweprotheni, iqela lophando lifumene i-181 yezakhi zofuzo phantsi ezilawulwayo kunye ne-82 yemfuza phezulu elawulwa ngokufumanisa ngokucwangcisiweyo iiseli eziphathwayo ze-spermidine, ngaphandle kwezakhi zofuzo ezinxulumene ne-melanogenesis.Ukuqhubela phambili ubungqina, iqela lophando lihlalutye umphumo we-spermidine kwinqanaba lokubonisa i-tyrosinase gene yentsapho ye-TYR, i-TRP-1 kunye ne-TRP-2, eziyimfuza elawula ngokusondeleyo ukuveliswa kwe-melanin.Inqanaba lokubonisa i-mRNA liqinisekisile ukuba i-spermidine ayizange iguqule ukubonakaliswa kwejene ezinxulumene ne-melanogenesis.Nangona kunjalo, umsebenzi wezakhi zofuzo ezininzi utshintshwa yi-spermidine kwaye ihambelana nokuthotywa kweprotheni.Iijini ezininzi ezitshintshileyo zinxulumene nokubiquity, okuyinkqubo yokuthotywa kweprotheyini enxulumene ne-melanogenesis.
三．Spermidine ilawula ukuzinza kweeprotheni kwaye ikhuthaza ukuveliswa kwe-melanin.
Ukuveliswa kwe-melanin kulawulwa yibhalansi ye-synthesis kunye nokuthotywa kweeprotheni ezinxulumene ne-melanin.I-Spermidine iphatha i-TYR, i-TRP-1 kunye ne-TRP-2 izakhi zofuzo.Ngokusebenzisa i-transporter genes SLC3A2, SLC7A1, SLC18B1 kunye ne-SLC22A18, inokunyusa izinga le-polyamines kwiiseli, ngaloo ndlela ikhulise ukuzinza kweeprotheni ezinxulumene nokuveliswa kwe-melanin ukukhuthaza ukuveliswa kwe-melanin kwi-vivo.
Ukuqukumbela, olu pho nonongo lubonisa ukuba i-spermidine yendalo yendalo inendima enokubakho kunyango lwe-hypopigmentation, kwaye inexabiso elithile lesicelo kwintsimi yezinto zokuthambisa kunye nemveliso yezempilo kwixesha elizayo.
Isalathiso:
[1] .Brito, S., Heo, H., Cha, B. et al.Ukuhlola okucwangcisiweyo kubonisa amandla e-spermidine yonyango lwe-hypopigmentation ngokuzinziswa kweeprotheni ezinxulumene ne-melanogenesis.Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Ixesha lokuposa: Sep-28-2022