Njengoko sikhula, amathambo ethu aya ebuthathaka kwaye aphuke lula, kwaye unyango lwangoku lunokunyusa uxinano lwamathambo kancinci. Le ngxaki ivela kakhulu kuba imbangela eyintloko ye-osteoporosis (ukuncipha kobunzima bamathambo kunye noxinano) ayaziwa.
Kutshanje, abaphandi base-Australia bapapashe iziphumo zophando lwenzululwazi kwiJournal of Gerontology: Series A: I-NMN inokunciphisa ukuguga kweeseli zamathambo omntu kwaye ikhuthaze ukuphiliswa kwamathambo kwiimpuku ze-osteoporotic. “Oku kufunyanisiweyo kubonisa ukuba i-NMN iyindlela yonyango esebenzayo nenokwenzeka yokuthintela i-osteoporosis kunye nokuphucula ukuphiliswa kwamathambo kubantu abadala abane-osteoporosis,” batsho ababhali.
一,I-NMNikhuthaza ukuvuselelwa kwee-osteoblasts kwaye yandisa ubungakanani bamathambo
Njengamanye amalungu omzimba womntu, amathambo enziwe ngeeseli eziphilayo. Ngenxa yoko, amathambo amadala nawonakeleyo ahlala ethathelwa indawo ngamatsha. Nangona kunjalo, njengoko sikhula, zimbalwa ii-osteoblast ezikhoyo, ngokuyinxenye kuba ii-osteoblast eziqhelekileyo ziba ziiseli ezisandul’ ukukhula. Iiseli ezisandul’ ukukhula, eziqhele ukuqhuba inkqubo yokwaluphala, azikwazi ukwenza ithambo elitsha, nto leyo ekhokelela kwi-osteoporosis.
Abaphandi base-Australia bafunde ngemiphumo ye-NMN kwi-osteoporosis ngokufunda nge-osteoblasts zabantu. Ukuze babangele ukuguga, abaphandi batyhile i-osteoblasts kwi-pro-inflammatory factor ebizwa ngokuba yi-TNF-⍺. Nangona i-TNF-⍺ ikhawulezisa ukuguga, unyango nge-NMN lunciphise ukuguga phantse kathathu, kwaye iziphumo zibonise ukuba i-NMN inciphise i-osteoblasts ezisandul’ ukukhula.
Ii-osteoblasts ezisempilweni zenza izicubu ezintsha zamathambo ngokuguqula zibe ziiseli zamathambo ezivuthiweyo. Abaphandi bafumanise ukuba ukubangela ukukhula nge-TNF-⍺ kunciphisa ubuninzi beeseli zamathambo ezivuthiweyo. Nangona kunjalo, i-NMN yonyusa ubuninzi beeseli zamathambo ezivuthiweyo, kwaye iziphumo zibonisa ukuba i-NMN inokukhuthaza ukwakheka kwamathambo.
Emva kokuba iziphumo zifumanise ukubaI-NMNAbaphandi bavavanye ukuba oku kunokwenzeka na kwizinto eziphilayo. Ukuze benze oku, basuse ama-ovari eempuku eziziimazi baza baqhekeza ii-femurs zazo, nto leyo ebangele ukulahleka kwamathambo okuluphawu lwe-osteoporosis.
Ukuvavanya impembelelo ye-NMN kwi-osteoporosis, abaphandi bafake i-400 mg/kg/ngosuku kwiimpuku ze-osteoporotic NMN kangangeenyanga ezi-2. Kufunyaniswe ukuba iimpuku ezine-osteoporosis zazinobunzima bamathambo obandayo, nto leyo ebonisa ukuba i-NMN iguqula kancinci iimpawu ze-osteoporosis. Xa idibene nedatha ye-osteoblast yomntu, oku kuthetha ukuba i-NMN inokukwazi ukunyanga i-osteoporosis ngokwandisa ukwakheka kwamathambo.
二、 Iziphumo zokuphucula amathambo e-NMN
Iziphumo zophando zibonisa ukubaI-NMNinokukhuthaza ukwakheka kwamathambo. Kubonakala ngathi yenza oku ngeendlela ezahlukeneyo, kuquka ukuvuselela iiseli ze-bone stem, ezibalulekileyo ekwakhekeni kwamathambo kunye ne-NAD+, ebalulekileyo ekwakhekeni kwamathambo. Iiseli ze-bone stem zahluka zibe zii-osteoblast, kwaye abaphandi babonise ukuba i-NMN inokuphinda ivuselele ii-osteoblast.
Ezi ziphumo zibonisa ukuba i-NMN inokunyusa ukwakheka kwamathambo ngokukhuthaza impilo yeeseli ezininzi zamathambo kwindlela yokwakheka kwamathambo. Nangona kungekho ziphumo zophando ezibonisa ukuba i-NMN inokukhuthaza ukwakheka kwamathambo kubantu abane-osteoporosis, kunokwenzeka ukuba i-NMN inokuthintela ukuphuhliswa kwamathambo okwenzeka ngokwaluphala.
Ixesha leposi: Jan-18-2024