Njengoko sikhula, amathambo ethu aba buthathaka kwaye athambekele ekuqhekekeni, kwaye unyango lwangoku lunokwandisa ngokuthozama ukuxinana kwamathambo.Le ngxaki ivela kakhulu ngenxa yokuba unobangela osisiseko we-osteoporosis (ukuncipha kwamathambo kunye nokuxinana) akwaziwa.
Kungekudala, abaphandi base-Australia bapapashe iziphumo zophando lwesayensi kwi-Journal ye-Gerontology: Uchungechunge A: I-NMN inokunciphisa ukuguga kweeseli zethambo lomntu kunye nokukhuthaza ukuphulukiswa kwamathambo kwiigundane ze-osteoporotic."Izinto ezifunyenweyo zibonisa i-NMN njengomviwa osebenzayo kwaye onokwenzeka wonyango ukukhusela i-osteoporosis kunye nokuphucula ukuphulukiswa kwamathambo kubantu abadala abadala abane-osteoporosis," ababhali bathi.
一,NMNikhuthaza ukuvuselelwa kwe-osteoblasts kwaye yandisa ubukhulu bamathambo
Njengamanye amalungu emzimbeni womntu, amathambo enziwe ngeeseli eziphilayo.Ngoko ke, amathambo amadala kunye nawonakele ahlala etshintshwa ngamatsha.Nangona kunjalo, njengoko sikhula, ii-osteoblasts ezimbalwa ziyafumaneka, ngokuyinxenye ngenxa yokuba ii-osteoblasts eziqhelekileyo ziba ziiseli ze-senescent.Iiseli ze-Senescent, ezinokuthi ziqhube inkqubo yokuguga, azikwazi ukwenza ithambo elitsha, elikhokelela kwi-osteoporosis.
Abaphandi base-Australia bafunde iziphumo ze-NMN kwi-osteoporosis ngokufunda i-osteoblasts yabantu.Ukukhuthaza i-senescence, abaphandi baveze i-osteoblasts kwi-pro-inflammatory factor ebizwa ngokuba yi-TNF-⍺.Nangona i-TNF-⍺ ikhawuleza ukuguga, unyango kunye ne-NMN lunciphisa ukuguga phantse ngamaxesha e-3, kwaye iziphumo zibonise ukuba i-NMN yanciphisa i-osteoblasts ye-senescent.
Ii-osteoblasts eziphilileyo zenza izicubu zethambo elitsha ngokuguqula zibe ziiseli zamathambo eziqolileyo.Abaphandi bafumanisa ukuba ukunyusa i-senescence nge-TNF-⍺ kunciphise ubuninzi beeseli zethambo ezivuthiweyo.Nangona kunjalo, i-NMN yandisa ubuninzi beeseli zethambo ezivuthiweyo, kwaye iziphumo zibonisa ukuba i-NMN inokukhuthaza ukubunjwa kwamathambo.
Emva kokuba iziphumo zifumanise okoNMNinokunciphisa i-osteoblasts ye-senescent kwaye ikhuthaze ukuhlukana kwabo kwiiseli zethambo ezivuthiweyo, abaphandi bavavanya ukuba oku kunokwenzeka kwizinto eziphilayo.Ukwenza oku, basusa ama-ovari eempuku ezibhinqileyo kwaye baqhekeza iifemurs zabo, okukhokelela ekulahlekelweni kwamathambo okuphawu lwe-osteoporosis.
Ukuvavanya umphumo we-NMN kwi-osteoporosis, abaphandi bafaka iigundane ze-osteoporotic kunye ne-400 mg / kg / ngosuku lwe-NMN kwiinyanga ze-2.Kwafunyaniswa ukuba iigundane ezine-osteoporosis zandise ubunzima bamathambo, nto leyo ebonisa ukuba i-NMN iguqule ngokuyinxenye iimpawu ze-osteoporosis.Idityaniswe neenkcukacha ze-osteoblast yabantu, oku kuthetha ukuba i-NMN inokukwazi ukunyanga i-osteoporosis ngokunyusa ukubunjwa kwamathambo.
二、 Iziphumo zokuphucula amathambo e-NMN
Iziphumo zophando zibonisa ukubaNMNinokukhuthaza ukubunjwa kwamathambo.Kubonakala kukwenza oku ngeendlela ezininzi, ezibandakanya ukuvuselela iiseli ze-stem zamathambo, eziyimfuneko ekwenziweni kwamathambo kunye ne-NAD +, eyimfuneko ekwenzeni amathambo.Iiseli ze-Bone stem ziyahlula kwii-osteoblasts, kwaye abaphandi baye babonisa ukuba i-NMN inokuvuselela i-osteoblasts.
Ezi ziphumo zibonisa ukuba i-NMN inokunyusa ukubunjwa kwamathambo ngokukhuthaza impilo yeeseli ezininzi zethambo kwindlela yokwakheka kwamathambo.Nangona akukho ziphumo zophando ezibonisa ukuba i-NMN inokukhuthaza ukubunjwa kwamathambo kubantu abane-osteoporosis, kunokwenzeka ukuba i-NMN inokuthintela ukuphuhliswa kwethambo okwenzeka ngobudala.
Ixesha lokuposa: Jan-18-2024