i-β-Nicotinamide adenine dinucleotide (i-asidi yasimahla) (i-NAD)
I-NAD yi-coenzyme eqhelekileyo ye-dehydrogenase kwizinto eziphilayo. Ithatha inxaxheba kwiimpendulo ze-redox kwizinto eziphilayo, kwaye ithutha kwaye idlulisele ii-electron kwizinto ezikwimpendulo. I-Dehydrogenase idlala indima ebalulekileyo kwi-metabolism yomntu. Ezinye iintshukumo ezisisiseko ze-metabolism zomzimba womntu, ezinje ngokubola kweproteni, ukubola kwe-carbohydrate, kunye nokubola kwamafutha, azinakwenziwa ngokuqhelekileyo ngaphandle kwe-dehydrogenase, kwaye abantu baya kulahlekelwa zizibonakaliso ezibalulekileyo. Kwaye kuba indibaniselwano ye-NAD kunye ne-dehydrogenase inokukhuthaza i-metabolism, ngoko ke i-NAD yinxalenye ebalulekileyo yomzimba womntu. Ngokwendlela esetyenziswa ngayo imveliso, inokwahlulwahlulwa ibe ngamanqanaba alandelayo: inqanaba le-biotransformation, inqanaba le-diagnostic reagent, inqanaba lokutya okunempilo, i-API kunye nezinto zokulungisa.
| Igama leKhemikhali | I-Nicotinamide adenine dinucleotide (i-asidi yasimahla) |
| Izithethantonye | i-β-Nicotinamide adenine dinucleotide |
| Inombolo ye-CAS | 53-84-9 |
| Ubunzima beMolekyuli | 663.43 |
| Ifomula yeMolekyuli | C21H27N7O14P2 |
| EINECS: | 200-184-4 |
| Indawo yokunyibilika | 140-142 °C (ukuhluza) |
| ubushushu bokugcina. | -20°C |
| ukunyibilika | H2O: 50 mg/mL |
| ifomu | Umgubo |
| umbala | Mhlophe |
| I-Merck | 14,6344 |
| I-BRN | 3584133 |
| Uzinzo: | Izinzile. Ayina-hygroscopic. Ayihambelani nee-oxidizing agents ezinamandla. |
| I-InChIKey | I-BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Into yoVavanyo | Iinkcukacha |
| Inkangeleko | Umgubo omhlophe ukuya komhlophe ocwebezelayo |
| Uhlalutyo lwe-UV spectral εkwi-260 nm kunye ne-pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Ukunyibilika | 25mg/mL 25mg/mL emanzini |
| Umxholo (ngohlalutyo lwe-enzyme kunye ne-ADH kwi-pH 10, kusetyenziswa i-spectrophotometer, i-abs.340nm, ngokusekelwe kwi-anhydrous) | ≥98.0% |
| Uvavanyo (olwenziwa yi-HPLC, olungenamanzi) | 98.0~102.0% |
| Ubumsulwa (ngokwe-HPLC, %indawo) | ≥99.0% |
| Umthamo wamanzi (ngokwe-KF) | ≤3% |
Iphakheji:Ibhotile, ibhegi yefoyile ye-aluminium, i-25kg/iDrum yekhadibhodi, okanye ngokweemfuno zomthengi.
Imeko Yokugcina:Gcina ivalwe ngokuqinileyo ebumnyameni, ukuze igcinwe ixesha elide, yigcine kwi-2 ~ 8℃.
Inqanaba lokuguqulwa kweBio: Ingasetyenziselwa ukwenziwa kwe-biocatalytic ye-pharmaceutical intermediates kunye ne-APIs, ikakhulu ngee-enzymes ze-catalytic, ezifana ne-ketoreductase (KRED), i-nitroreductase (NTR), i-P450 monooxygenase (CYP), i-formate dehydrogenase (FDH) ), i-glucose dehydrogenase (GDH), njl.njl., ezinokusebenzisana ukuguqula ii-amino acid intermediates ezahlukeneyo kunye nezinye iziyobisi ezinxulumene noko. Okwangoku, iifektri ezininzi zamayeza zasekhaya ziqalile ukusebenzisa indawo ye-enzyme yebhayoloji, kwaye imfuno yemarike ye-NAD+ ikhula ngokukhawuleza.
Uhlobo lwe-reagent yokuxilonga: Idityaniswe nee-enzymes ezahlukeneyo zokuxilonga, njengezinto ezisetyenziswa kwiikiti zokuxilonga.
Udidi lokutya okunempilo: I-NAD yi-coenzyme ye-dehydrogenase. Idlala indima engenakutshintshwa kwi-glycolysis, i-gluconeogenesis, umjikelo we-tricarboxylic acid, kunye ne-respiratory chain, idlala indima ebalulekileyo ekuvelisweni kwamandla, kwaye inceda ekuvelisweni kwe-L-dopa, eba yi-dopamine Neurotransmitters. Ingakumbi kwiminyaka yakutshanje, kufunyaniswe ukuba "yi-injini" kunye "ne-fuel" kwinkqubo yokulungisa umonakalo weseli. Ngokophando, ukongezwa kwee-coenzymes (kuquka i-NMN, i-NR, i-NAD, i-NADH) kwi-vitro kunokuphucula amandla e-antioxidant eeseli zezicubu, kuthintele i-apoptosis signaling, kubuyisele ukusebenza kweseli okuqhelekileyo, kuthintele ukwenzeka kwesifo okanye kuthintele ukuqhubeka kwesifo.
Ukongeza, ii-coenzymes zinokuphucula amandla okuphendula komzimba ngokuvuselela nokukhuthaza ukuvuthwa kweeseli zomzimba ezizalwa nazo, zivelise izinto ezichasene nokuvuvukala kwaye zicinezele iiseli ze-T ezilawulayo. Imeko ye-oxidation ye-Nicotinamide dinucleotide (NAD+) yi-coenzyme efumaneka kuzo zonke iiseli eziphilayo. Idlala indima ebalulekileyo kumakhulu eenkqubo ze-metabolic kwiiseli, ithatha inxaxheba kumawaka eempendulo zomzimba, kwaye lilungu elibalulekileyo lekhonkco lothutho lwe-electron. Umnikeli we-hydrogen; kwangaxeshanye, i-coenzyme I isebenza njengesiseko sodwa see-enzymes ezinxulumene nazo emzimbeni, inceda ukugcina umsebenzi wee-enzymes.
I-Nicotinamide mononucleotide (NMN) yi-compound eyandulela i-nicotinamide adenine dinucleotide oxidation state (NAD+), ebandakanyeka ekwenziweni kwe-NAD in vivo. Ngo-2013, uNjingalwazi uDavid Sinclair weHarvard Medical School wafumanisa ukuba ngokukhula, inqanaba le-cofactor coenzyme I (NAD+) leprotheyini yokuphila ixesha elide emzimbeni liyaqhubeka nokuhla, nto leyo ekhokelela ekwehleni komsebenzi we-mitochondrial we-"dynamo" yeseli, okubangela ukwaluphala, kunye nezinto ezahlukeneyo emzimbeni. Ukungasebenzi kakuhle kolu hlobo lomsebenzi kuveliswa ngaloo ndlela. Ngokoluhlu lwezifundo zakhe, umxholo we-NAD+ emzimbeni womntu uyancipha ngokukhula, nto leyo ebangela ukwaluphala okukhawulezileyo ukusuka kwiminyaka engama-30, kunye nemibimbi, ukuphumla kwemisipha, ukuqokelelwa kwamafutha, kunye nezifo ezifana nesifo sentliziyo, uxinzelelo lwegazi oluphezulu, isifo sohlangothi, isifo seswekile kunye nesifo se-Alzheimer okwandisiweyo umngcipheko. Isitshixo sokuphila ixesha elide kukunyusa inqanaba le-coenzyme I (NAD+) emzimbeni, ukunyusa izinga le-metabolism yeseli, kunye nokukhuthaza amandla obutsha anokubakho.
I-API kunye nokulungiselela izinto eziluhlaza: I-NAD+ isetyenziswa kwiinaliti zonyango/ulawulo lomlutha weziyobisi, kuquka unyango lwe-NAD IV olufakwa kwimithambo oluqhutywa eMelika, eYurophu, eRashiya, eMzantsi Afrika, eMexico, eMzantsi Melika, eMzantsi-mpuma Asia nakwamanye amazwe. Iimveliso zekhemesti ezizilungiselela zona, ezifana neekhemesti zaseMelika, zinokuthenga izinto eziluhlaza ukuze zithengiswe zodwa, njengezinto ezilungiselelwe izibhedlele zaseTshayina, ilawula umgangatho wezinto eziluhlaza zodwa, kwaye ilungiselela izinto eziluhlaza zibe ngamayeza.
