I-β-Nicotinamide adenine dinucleotide (i-asidi yasimahla) (NAD)
I-NAD yicoenzyme eqhelekileyo ye-dehydrogenase kwizinto eziphilayo.Ithatha inxaxheba kwi-redox reactions kwizinto eziphilayo, kwaye ithutha kwaye idlulisele ii-electron zezinto kwi-reaction.I-Dehydrogenase idlala indima egqibeleleyo kwimetabolism yabantu.Ezinye iintshukumo ezisisiseko zemetabolism emzimbeni womntu, njengokubola kweprotheyini, ukubola kwecarbohydrate, kunye nokubola kwamafutha, akunakuqhutywa ngokuqhelekileyo ngaphandle kwe-dehydrogenase, kwaye abantu baya kulahlekelwa iimpawu ezibalulekileyo.Kwaye ngenxa yokuba indibaniselwano ye-NAD kunye ne-dehydrogenase inokukhuthaza i-metabolism, ke i-NAD yinxalenye eyimfuneko emzimbeni womntu.Ngokutsho kokusetyenziswa kwemveliso, inokwahlulwa ngokwala mabanga alandelayo: ibakala le-biotransformation, ibakala lokuxilonga i-reagent, ibakala lokutya kwezempilo, i-API kunye nokulungiselela izinto ezikrwada.
| Igama leMchiza | INicotinamide adenine dinucleotide (iasidi yasimahla) |
| Izithethantonye | β-Nicotinamide adenine dinucleotide |
| Inombolo yeCAS | 53-84-9 |
| Ubunzima beMolekyuli | 663.43 |
| Ifomula yeemolekyuli | I-C21H27N7O14P2 |
| EINECS: | 200-184-4 |
| Indawo yokunyibilika | 140-142 °C (ukonakala) |
| ixesha lokugcina. | -20°C |
| ukunyibilika | H2O: 50 mg/mL |
| ifomu | Umgubo |
| umbala | Mhlophe |
| Merck | 14,6344 |
| I-BRN | 3584133 |
| Uzinzo: | Izinzile.Hygroscopic.Ayihambelani ne-oxidizing agents ezinamandla. |
| I-InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Into yovavanyo | Iinkcukacha |
| Imbonakalo | Umgubo wekristale omhlophe ukuya kumhlophe |
| Uhlalutyo lwe-UV spectral εkwi-260 nm kunye ne-pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Ukunyibilika | 25mg/mL 25mg/mL emanzini |
| Umxholo (ngohlalutyo lwe-enzymatic kunye ne-ADH kwi-pH 10, usebenzisa i-spectrophotometer, i-abs.340nm, kwisiseko se-anhydrous) | ≥98.0% |
| Uvavanyo (nge-HPLC, ngokwesiseko se-anhydrous) | 98.0~102.0% |
| Ubunyulu (nge-HPLC, % indawo) | ≥99.0% |
| Isiqulatho samanzi (nge-KF) | ≤3% |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Gcina ubambekile ebumnyameni, kuba ugcino ixesha elide gcina ku-2~8℃.
I-Biotransformation grade: Ingasetyenziselwa i-biocatalytic synthesis ye-pharmaceutical intermediates kunye ne-APIs, ngokukodwa kunye ne-catalytic enzymes, njenge-ketoreductase (KRED), i-nitroreductase (NTR), i-P450 monooxygenase (CYP), i-formate dehydrogenase (FDH) ), i-glucose dehydrogenase ( GDH), njl., ezinokusebenzisana ekuguquleni i-amino acid intermediates ezahlukeneyo kunye namanye amachiza anxulumeneyo.Okwangoku, iifektri ezininzi zasekhaya zamayeza sele ziqalisile ukusebenzisa indawo ye-enzyme yebhayoloji, kwaye imfuno yentengiso ye-NAD + ikhula ngokukhawuleza.
I-Diagnostic reagent grade: Idityaniswe neentlobo ezahlukeneyo ze-enzymes zokuxilonga, njengezinto ezibonakalayo zeekiti zokuxilonga.
Ibakala lokutya okunempilo: I-NAD yi-coenzyme ye-dehydrogenase.Idlala indima engenakuthathelwa indawo kwi-glycolysis, gluconeogenesis, umjikelo we-tricarboxylic acid, kunye nekhonkco lokuphefumla, idlala indima ebalulekileyo kwimveliso yamandla, kwaye inceda kwimveliso ye-L-dopa, eba yi-dopamine Neurotransmitters.Ingakumbi kwiminyaka yakutshanje, kuye kwafunyaniswa ukuba yi "injini" kunye "nefuel" kwinkqubo yokulungiswa komonakalo weseli.Ngokophando, ukuxhaswa kwee-coenzymes (kubandakanya i-NMN, NR, NAD, NADH) kwi-vitro inokuphucula amandla e-antioxidant yeeseli zezicubu, inqanda ukubonakaliswa kwe-apoptosis, ukubuyisela ukusebenza kweeseli eziqhelekileyo, ukuthintela ukwenzeka kwesifo okanye ukuthintela ukuqhubeka kwesifo.
Ukongezelela, i-coenzymes inokuphucula amandla okuphendula komzimba ngokusebenza kunye nokukhuthaza ukuvuthwa kwamaseli omzimba angaphakathi, ukuvelisa izinto ezichasayo kunye nokunyanzeliswa kweeseli ze-T ezilawulayo. I-Nicotinamide dinucleotide oxidation state (NAD +) yi-coenzyme efumaneka kuzo zonke iiseli eziphilayo.Idlala indima ebalulekileyo kumakhulu eenkqubo ze-metabolic kwiiseli, ithatha inxaxheba kumawaka eempendulo ze-physiological, kwaye lelona lungu libaluleke kakhulu kwikhonkco lokuthutha i-electron.Umxhasi weHydrojeni;kwangaxeshanye, i-coenzyme I isebenza njengeyona ndawo iphantsi kwee-enzymes ezinxulumeneyo emzimbeni, inceda ukugcina umsebenzi wee-enzymes.
I-Nicotinamide mononucleotide (NMN) yi-precursor compound ye-nicotinamide adenine dinucleotide oxidation state (NAD+), ebandakanyeka kwi-synthesis ye-NAD kwi-vivo.Kwi-2013, uNjingalwazi uDavid Sinclair waseHarvard Medical School wafumanisa ukuba ngokuguga, i-cofactor coenzyme I (NAD +) inqanaba leprotheyini yokuphila ixesha elide emzimbeni liyaqhubeka nokuhla, okukhokelela ekunciphiseni komsebenzi we-mitochondrial we "dynamo" yeseli, ebangela ukuguga. , kunye nezinto ezahlukeneyo emzimbeni.Ukungasebenzi kakuhle kolu hlobo lomsebenzi kuveliswe njalo.Ngokoluhlu lwezifundo zakhe, umxholo we-NAD + emzimbeni womntu uyancipha ngenxa yobudala, okukhokelela ekugugeni okukhawulezileyo ukusuka kwiminyaka engama-30, nemibimbi, ukuphumla kwemisipha, ukuqokelelwa kwamafutha, kunye nezifo ezinje ngesifo sentliziyo, uxinzelelo lwegazi oluphezulu, istroke. , isifo seswekile kunye nesifo se-Alzheimer sandisa ingozi.Isitshixo sobomi obude kukunyusa inqanaba le-coenzyme I (NAD +) emzimbeni, ukwandisa izinga le-cell metabolism, kunye nokuvuselela amandla olutsha olutsha.
I-API kunye nokulungiselela izinto ezingasetyenziswanga: I-NAD + isetyenziswa kwiinaliti kunyango/ulawulo lweziyobisi, kubandakanya ne-NAD IV yonyango lwe-intravenous oluphunyezwe eUnited States, eYurophu, eRashiya, eMzantsi Afrika, eMexico, eMzantsi Melika, eMzantsi-mpuma Asia nakwamanye amazwe.Iimveliso ezizilungiselele ekhemesti, ezifana neekhemesti zaseMelika, zinokuthenga izinto ezingasetyenziswanga ukuze zihanjiswe ngokwazo, njengamalungiselelo esibhedlele saseTshayina, ilawula umgangatho wezinto eziluhlaza ngokwawo, kwaye ilungiselela amalungiselelo kumayeza.
