I-β-Nicotinamide Mononucleotide (NMN)
Kutshanje, kukho iindaba ezilungileyo kwintsimi ye-NMN - emva kokuphononongwa ngokungqongqo yikomiti yeengcali ze-US Food and Drug Administration (FDA) umbutho ogunyazisiweyo, izixhobo ze-NMN ze-Shangke Biopharmaceutical (Shanghai) Co., Ltd. ukuya njenge "Shangke Bio") ivunyiwe yi-United States imvume ye-FDA NDI iqinisekisa ukuba izinto zayo eziluhlaza ze-NMN zingasetyenziswa ngokusemthethweni kwimveliso, ukuthengisa kunye nokukhuthaza izongezo zokutya e-United States, kwaye inokufumaneka kwigosa le-FDA. Iwebhusayithi njengesongezelelo sesondlo esitsha semathiriyeli ekrwada, inombolo 1247.
I-FDA NDI yeyona nkqubo ibalulekileyo yokuqinisekisa kwiimarike zase-US.Ukufumana esi satifikethi akuthethi nje ukuba ukhuseleko kunye nomgangatho weemveliso ze-Shangke Bio ziyamkelwa kakhulu, kodwa ikwaluncedo kuphuhliso olusemgangathweni oluqhubekayo loshishino lwe-NMN ekuhambeni kwexesha.
| Igama leMchiza | β-Nicotinamide Mononucleotide |
| Izithethantonye | NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE |
| Inombolo yeCAS | 1094-61-7 |
| Ubunzima beMolekyuli | 334.22 |
| Ifomula yeemolekyuli | I-C11H15N2O8P |
| EINECS: | 214-136-5 |
| Indawo yokunyibilika | 166 °C(dec.) |
| ixesha lokugcina. | -20°C |
| ukunyibilika | I-DMSO (Kancinci, ishushu), iMethanol (Kancinci), Amanzi (Kancinci) |
| ifomu | Iqinile |
| umbala | Mhlophe ukuya kumthubi |
| Merck | 13,6697 |
| I-BRN | 3570187 |
| Uzinzo: | I-Hygroscopic kakhulu |
| I-InChIKey | I-DAYLJWODMCOQEW-TURQNECASA-N |
| Into yovavanyo | Iinkcukacha |
| Imbonakalo | Umgubo wekristale omhlophe ukuya kumhlophe |
| Umxholo wesodium | ≤1% |
| ixabiso pH (100mg/ml) | 2.0~4.0 |
| Ubunyulu | ≥99.0% |
| Isiqulatho samanzi | ≤1% |
| Iintsimbi ezinzima | <10ppm |
| Arsenic | <0.5ppm |
| Inkokeli | <0.5ppm |
| IMercury | <0.1ppm |
| I-Cadmium | <0.5ppm |
| Intsalela yokunyibilikisa | I-Ethanol≤1000ppm |
| Ubalo lweAerobic Microbial iyonke | <750cfu/g |
| Igwele kunye noMngundo | <25cfu/g |
| I-coliform epheleleyo | ≤0.92MPN/g |
| E. Coli | Ibi |
| Salmonella | Ibi |
| Staph.Aureus | Ibi |
| Uvavanyo (kwisiseko se-anhydrous) | ≥99.0% |
| Izinga lokucoca | ≥95% |
| Unizi lolwapho kuyiwa khona | Ingxelo yolwazi |
Umqulu:Ibhotile, ingxowa yefoyile yeAluminiyam, 25kg/Igubu lekhadibhodi, okanye ngokwemfuno yomthengi.
Imeko yoGcino:Londoloza kwizikhongozeli eziqinile, ezikwaziyo ukumelana nokukhanya, ukwenzela ukugcina ixesha elide ku-2–8°C okanye ngaphantsi.
I-Nicotinamide Mononucleotide (NMN) yinguqulelo entsha ye-vitamin B3 eyi-1 yesinyathelo esandulelayo kwi-NAD + (iNicotinamide Adenine Dinucleotide).I-NMN yeyokuqala i-NAD+ ebuyisela iselula ukuba ingqinwe iyasebenza ukubuyisela iiseli kwi-vivo.
INicotinamide Adenine Dinucleotide (NAD) yenye yezona molekyuli zibalulekileyo kwaye zinomdla emzimbeni.Iyadingeka ngaphezu kwe-500 yokuphendula kwe-enzymatic kwaye idlala indima ebalulekileyo ekulawuleni phantse zonke iinkqubo zebhayoloji eziphambili (Ansari noRaghava, 2010).Ngaphezu kwako konke, kunokusivumela ukuba siphile ubomi obusempilweni nobude obude.
I-Nicotinamide Adenine Dinucleotide (NAD) ikhona nokuba ikwimo yayo ene-oxidized (NAD+) okanye ifom encitshisiweyo (NADH), eziyi-cofactors ezibalulekileyo zenani le-oxireductases.
I-SyncoZyems njengowokuqala ukufumana i-FDA NDINMN evunyiweyo yeshishini lokuvelisa izinto ekrwada, imele igosa le-FDA lamkele i-NMN njengohlobo olutsha lwezinto ezinokuqala ukwamkelwa kwaye zivunywe kwizithako ezongezelelweyo zokutya e-United States.
