I-β-Nicotinamide Mononucleotide (NMN)
Kutshanje, kukho iindaba ezimnandi kwicandelo le-NMN - emva kokuphononongwa ngokungqongqo yikomiti yobungcali yombutho ogunyazisiweyo we-US Food and Drug Administration (FDA), izinto eziluhlaza ze-NMN zeShangke Biopharmaceutical (Shanghai) Co., Ltd. (eza kubizwa ngokuba yi "Shangke Bio") zivunyiwe yi-United States. Imvume ye-FDA NDI iqinisekisa ukuba izinto eziluhlaza zayo ze-NMN zingasetyenziswa ngokusesikweni kwimveliso, ukuthengisa kunye nokukhuthaza izongezo zokutya e-United States, kwaye zinokufumaneka kwiwebhusayithi esemthethweni ye-FDA njengezinto ezintsha eziluhlaza zezongezo zokutya, inombolo 1247.
I-FDA NDI yeyona nkqubo ibalulekileyo yokuqinisekisa kwimarike yaseMelika. Ukufumana esi siqinisekiso akuthethi nje kuphela ukuba ukhuseleko kunye nomgangatho weemveliso zeShangke Bioiyaqatshelwa kakhulu, kodwa ikwanceda ekuphuhlisweni okuqhelekileyo okuqhubekayo koshishino lwe-NMN ekuhambeni kwexesha.
| Igama leKhemikhali | I-β-Nicotinamide Mononucleotide |
| Izithethantonye | I-NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE |
| Inombolo ye-CAS | 1094-61-7 |
| Ubunzima beMolekyuli | 334.22 |
| Ifomula yeMolekyuli | C11H15N2O8P |
| EINECS: | 214-136-5 |
| Indawo yokunyibilika | 166 °C (ngoDisemba) |
| ubushushu bokugcina. | -20°C |
| ukunyibilika | I-DMSO (Kancinci, Ishushu), i-Methanol (Kancinci), Amanzi (Kancinci) |
| ifomu | Iqinile |
| umbala | Umhlophe ukuya kuMthubi |
| I-Merck | 13,6697 |
| I-BRN | 3570187 |
| Uzinzo: | I-Hygroscopic kakhulu |
| I-InChIKey | I-DAYLJWODMCOQEW-TURQNECASA-N |
| Into yoVavanyo | Iinkcukacha |
| Inkangeleko | Umgubo omhlophe ukuya komhlophe ocwebezelayo |
| Umxholo wesodiyam | ≤1% |
| Ixabiso le-pH (100mg/ml) | 2.0~4.0 |
| Ubunyulu | ≥99.0% |
| Umthamo wamanzi | ≤1% |
| Iintsimbi ezinzima | <10ppm |
| I-Arsenic | <0.5ppm |
| Inkokeli | <0.5ppm |
| I-Mercury | <0.1ppm |
| I-Cadmium | <0.5ppm |
| Intsalela yesinyibilikisi | I-Ethanol≤1000ppm |
| Inani elipheleleyo leeMicrobial ze-Aerobic | <750cfu/g |
| Imvubelo kunye noMngundo | <25cfu/g |
| I-coliform iyonke | ≤0.92MPN/g |
| E. Coli | Okungalunganga |
| I-Salmonella | Okungalunganga |
| UStaph. Aureus | Okungalunganga |
| Uvavanyo (ngokusekelwe kwi-anhydrous) | ≥99.0% |
| Izinga lokuhluma | ≥95% |
| Unizi lolwapho kuyiwa khona | Xela ulwazi |
Iphakheji:Ibhotile, ibhegi yefoyile ye-aluminium, i-25kg/iDrum yekhadibhodi, okanye ngokweemfuno zomthengi.
Imeko Yokugcina:Gcina kwiikhonteyina eziqinileyo nezimelana nokukhanya, ukuze zigcinwe ixesha elide, zigcine kwi-2~8°C okanye ngaphantsi.
I-Nicotinamide Mononucleotide (NMN) yinguqulelo entsha ye-vitamin B3 eyinyathelo eli-1 lokuqala kwi-NAD+ (Nicotinamide Adenine Dinucleotide). I-NMN yi-restorer yokuqala ye-NAD+ yeselula eqinisekisiweyo ukuba iyasebenza ekubuyiseleni iiseli emzimbeni.
I-Nicotinamide Adenine Dinucleotide (NAD) yenye yeemolekyuli ezibalulekileyo nezinomdla emzimbeni. Iyimfuneko kwiimpendulo ze-enzyme ezingaphezu kwama-500 kwaye idlala indima ebalulekileyo ekulawuleni phantse zonke iinkqubo eziphambili zebhayoloji (u-Ansari no-Raghava, 2010). Ngaphezu kwako konke, inokusivumela ukuba siphile ubomi obusempilweni nobude.
I-Nicotinamide Adenine Dinucleotide (NAD) ikhona nokuba ikwimo yayo ye-oxidized (NAD+) okanye ikwimo encitshisiweyo (NADH), eziyi-cofactors ezibalulekileyo zenani lee-oxireductases.
I-SyncoZyems njengeyokuqala ukufumana inkampani yemveliso yezinto ezikrwada evunyiweyo yi-FDA NDI NMN, imele igosa le-FDA ukuba liyamkela i-NMN njengohlobo olutsha lwezinto ezinokwamkelwa kwaye zivunywe njengezithako zezongezo zokutya eMelika.
