Umfanekiso obonisiweyo we-Aldolase (DERA)

I-Aldolase (i-DERA)

Inkcazo emfutshane:

I-ES-DERA: Ingavuselela ngempumelelo ukongezwa kwee-ketones ze-donor kwi-receptor aldehydes. Ngaphezu koko, impendulo ingenziwa kwisisombululo samanzi se-pH engathathi hlangothi ngaphandle kwamanyathelo akhethekileyo okukhusela. Zikwi-aldolase yeklasi I, eyenza isiseko seShiff kwinkqubo ye-catalytic. I-substrate idityaniswe ngokudibeneyo neqela le-amino lendawo esebenzayo ukuqala ukwaphuka nokwakheka kwe-bond. Umahluko phakathi kwe-DERAs kunye nezinye i-aldolases kukuba i-substrates abazivuselelayo zi-aldehydes kwaye zinokuqhubeka nokufuma kwe-aldehydes.

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I-imeyile:lchen@syncozymes.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Malunga ne-Aldolase:

Kukho iintlobo ezisi-8 zeemveliso ze-aldolase (Inombolo njenge-ES-DERA-101 ~ ES-DERA-108) eziphuhliswe yiSyncoZymes. I-SZ-DERA sisixhobo esiluncedo sokushukumisa ukwakheka kwebhondi ye-carbon-carbon ene-enantioselective, evelisa amaziko amabini e-chiral phantsi kweemeko zokusabela okuncinci.

Uhlobo lwempendulo ye-Catalytic:

Indlela yokwenza i-catalytic:

Ulwazi lweMveliso:

Iienzymes	Ikhowudi yeMveliso	Inkcazo
Umgubo we-Enzyme	ES-DERA-101~ ES-DERA-108	iseti ye-8 Aldolase, 50 mg nganye Izinto ezi-8 * 50mg / into, okanye olunye ubungakanani
Isixhobo sokuvavanya (iSynKit)	I-ES-DERA-800	iseti ye-8 Aldolase, 1 mg nganye Izinto ezi-8 * 1mg / into

Iingenelo:

★ Uluhlu olubanzi lwe-substrate.
★ Uguquko oluphezulu.
★ Iimveliso ezingaphantsi kwezinye.
★ Iimeko zokusabela okuncinci.
★ Inobuhlobo nokusingqongileyo.

Imiyalelo yokusebenzisa:

➢ Ngokwesiqhelo, inkqubo yokusabela kufuneka iquke i-substrate, isisombululo se-buffer (i-pH yempendulo efanelekileyo) kunye ne-ES-DERA.
➢ Zonke iintlobo ze-ES-DERA ezihambelana neemeko ezahlukeneyo zokusabela ezifanelekileyo kufuneka zifundwe nganye nganye.
➢ I-ES-DERA kufuneka yongezwe okokugqibela kwinkqubo yokusabela ukuze kugcinwe umsebenzi.
➢ I-substrate enoxinzelelo oluphezulu okanye imveliso enayo inokuthintela umsebenzi we-ES-DERA. Nangona kunjalo, uthintelo lunokupheliswa ngokongeza i-substrate ngebhetshi.