I-Aldolase (DERA)

Inkcazelo emfutshane:

I-ES-DERAs: Inokwenza ngokufanelekileyo ukongezwa kwe-stereoelective yee-ketones zabaxhasi kwi-receptor aldehydes.Ngaphezu koko, ukusabela kunokwenziwa kwisisombululo esimanzi se-pH engathathi hlangothi ngaphandle kwamanyathelo okukhusela akhethekileyo.Bangabeklasi I aldolase, eyenza isiseko sikaShiff kwinkqubo ye-catalytic.I-substrate ihlanganiswe ngokubambisana kunye neqela le-amino lendawo esebenzayo ukuqalisa ukuphuka kunye nokwakhiwa kwebhondi.Umahluko phakathi kwe-DERAs kunye nezinye ii-aldolases kukuba ii-substrates ezizenza zi-aldehydes kwaye zinokungena kwi-aldehydes condensation eqhubekayo.

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I-imeyile:lchen@syncozymes.com

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Iinkcukacha zeMveliso

Iithegi zeMveliso

Malunga ne-Aldolase:

Kukho iintlobo ezisi-8 zeemveliso ze-aldolase (Inombolo njenge-ES-DERA-101～ES-DERA-108) ephuhliswe yi-SyncoZymes.I-SZ-DERA sisixhobo esiluncedo sokwenza i-enantioselective carbon-carbon bond bond, ivelise ukuya kumaziko amabini e-chiral phantsi kweemeko zokusabela kancinci.

Uhlobo lwe-Catalytic reaction:

Indlela yokwenza:

Ulwazi ngeMveliso:

Iienzymes	Ikhowudi yeMveliso	Inkcazo
Umgubo we-Enzyme	ES-DERA-101~ ES-DERA-108	iseti ye-8 Aldolase, 50 mg nganye 8 izinto * 50mg / into, okanye enye ubungakanani
Ikhithi yokuHlola (SynKit)	ES-DERA-800	iseti ye-8 Aldolase, 1 mg nganye 8 izinto * 1mg / into

Izinto eziluncedo:

★ I-spectrum ebanzi yesubstrate.
★ ukuguqulwa okuphezulu.
★ Iimveliso ezingaphantsi kweemveliso.
★ Iimeko zokusabela ezithambileyo.
★ Ilungele indalo.

Imiyalelo yokusetyenziswa:

➢ Ngokuqhelekileyo, inkqubo yokusabela kufuneka ibandakanye i-substrate, isisombululo se-buffer (optimum reaction pH) kunye ne-ES-DERA.
➢ Zonke iintlobo zee-ES-DERA ezihambelana neemeko ezahlukeneyo zokusabela kufuneka zifundwe zodwa.
➢ I-ES-DERA kufuneka yongezwe okokugqibela kwisistim yokusabela ukugcina umsebenzi.
➢ Uxinzelelo oluphezulu lweSubstrate okanye imveliso enento enokuthintela umsebenzi weES-DERA.Nangona kunjalo, isithintelo sinokukhululeka ngokongezwa kwebhetshi ye-substrate.