SyncoZymes

iimveliso

IiOxynitrilases (HNL)

Inkcazelo emfutshane:

Malunga ne-oxynitrilases

I-ES-HNLs: I-enzyme yeklasi eyenza i-enantioselectively i-catalyze ukongezwa kwe-HCN kwi-aldehydes (i-ketones) ukufumana i-R okanye i-S yohlobo lwe-cyanide alcohols, enokuguqulwa ngokulula kwiindidi ezininzi zeziyobisi okanye izibilini zeziyobisi ngokusebenzisa indlela yekhemikhali.
Kukho iintlobo ze-29 zeemveliso ze-oxynitrilase (Inombolo njenge-ES-HNL-101~ES-HNL-129) ephuhliswe ngu-SyncoZymes.I-SZ-HNL sisixhobo esiluncedo kwi-regio- kunye ne-stereo- selective synthesis ye (R) -cyanohydrins okanye (S) -cyanohydrins evela kwiindidi ze-aldehydes ezivumba, i-aliphatic kunye ne-heterocyclic okanye i-ketones.
Uhlobo lwe-Catalytic reaction:

Oxynitrilases HNL2

Iselula/Wechat/WhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com


Iinkcukacha zeMveliso

Iithegi zeMveliso

Ulwazi ngeMveliso:

Oxynitrilases HNL
Iienzymes Ikhowudi yeMveliso Inkcazo
Umgubo we-Enzyme ES-HNL-101~ ES-HNL-129 iseti ye-29 oxynitrilases, 50 mg nganye 29 izinto * 50mg / into, okanye enye ubungakanani
Ikhithi yokuHlola (SynKit) ES-HNL-1800 iseti ye-18 (S) -oxynitrilases, 1 mg nganye 18 izinto * 1mg / into
Ikhithi yokuHlola (SynKit) ES-HNL-1100 iseti ye-11 (R) -oxynitrilases, 1 mg nganye 11items * 1mg / into

Izinto eziluncedo:

★ Ubucacileyo besubstrate ephezulu.
★ Ukukhetha okuqinileyo kwe-chiral.
★ ukuguqulwa okuphezulu.
★ Iimveliso ezingaphantsi kweemveliso.
★ Iimeko zokusabela ezithambileyo.
★ Ilungele indalo.

Imiyalelo yokusetyenziswa:

➢ Ngokuqhelekileyo, inkqubo yokusabela kufuneka ibandakanye i-substrate (aldehydes / ketones, HCN), isisombululo se-buffer (optimum reaction pH) kunye nee-enzymes.
➢ Zonke ii-ES-HNLs zinokuvavanywa ngokulandelelanayo kwi-reaction system engentla okanye nge-HNL Screening Kit (SynKit HNL).
➢ Zonke iintlobo zee-ES-HNL ezingqamene neemeko ezahlukeneyo zokusabela kufuneka zifundwe zodwa.
➢ Uxinzelelo oluphezulu lweSubstrate okanye imveliso enayo inokuthintela ukusebenza kweES-HNL.Nangona kunjalo, isithintelo sinokukhululeka ngokongezwa kwebhetshi ye-substrate.

Imizekelo yosetyenziso:

Umzekelo 1(1):

Oxynitrilases HNL3

Ugcino:

Gcina iminyaka emi-2 ngaphantsi -20 ℃.

Ingqalelo:

Ungaze udibane neemeko ezigqithisileyo ezinje: ubushushu obuphezulu, i-pH ephezulu/ephantsi kunye noxinzelelo oluphezulu lwe-organic solvent.

IiReferensi:

1 Langermann J, Guterl JK, Pohl M, e tal.I-Bioprocess Biosyst Eng, i-2008, i-31: 155-161.


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