I-Benzaldehyde lyase (BAL)
Inkcazelo emfutshane:
Malunga neBenzaldehyde lyase
I-ES-BAL (i-Benzaldehyde lyase): uhlobo lwe-enzyme eyenza i-hydroxymethylation ye-aldehydes enuka kunye ne-aliphatic ene-formaldehyde ukuvelisa i-α-Hydroxymethyl ketone ehambelanayo.I-BAL yi-thiamine diphosphate (ThDP) - i-enzyme exhomekeke.Kukho kuphela uhlobo olu-1 lwemveliso ye-enzyme ye-BAL (Inombolo njenge-ES-BAL101) ephuhliswe yi-SyncoZymes, engasetyenziselwa i-hydroxymethylation ye-aldehydes enuka kunye ne-aliphatic.
Uhlobo lwe-Catalytic reaction:
Iselula/Wechat/WhatsApp: +86-13681683526
I-imeyile:lchen@syncozymes.com
★ Ubucacileyo besubstrate ephezulu.
★ Ukukhetha okuqinileyo kwe-chiral.
★ ukuguqulwa okuphezulu.
★ Iimveliso ezingaphantsi kweemveliso.
★ Iimeko zokusabela ezithambileyo.
★ Ilungele indalo.
➢ Ngokuqhelekileyo, inkqubo yokusabela kufuneka ibandakanye i-substrate, isisombululo se-buffer, i-enzyme, i-ThDP, i-Mg2+.
➢ I-BAL kufuneka yongezwe okokugqibela kwisistim yokusabela, emva kokuba i-pH kunye nobushushu bulungelelaniswe kwimeko yokusabela.
Umzekelo 1(I-Synthesis ye-N-ifakwe endaweni ye-1,2 ye-amino alcohols evela kwi-aldehydes)(1):
Gcina iminyaka emi-2 ngaphantsi -20 ℃.
Ungaze udibane neemeko ezigqithisileyo ezinje: ubushushu obuphezulu, i-pH ephezulu/ephantsi kunye noxinzelelo oluphezulu lwe-organic solvent.
1. ULi Y, uHu N, uXu Z, nabanye.I-Angewandte Chemie International Edition, 2022, 61(17): e202116344.
