I-Ketoreductase (KRED)

Inkcazelo emfutshane:

Malunga neKetoreductase

Ii-Enzymes: Ngaba zii-macromolecular biological catalysts, uninzi lwee-enzymes ziiproteni.

I-Ketoreductase: Ekwabizwa ngokuba “yiCarbonyl reductase”, zii-enzymes ezenza ukuba i-redox ibuye umva phakathi kwe-aldehydes / ii-ketones kunye ne-alcohol, kwaye idinga ii-coenzymes njenge-H transmitter njenge-NADH okanye i-NADPH.Kukho iindidi ezintathu eziphambili ze-KRED: I-Dehydrogenase ye-Short-chain / Reductases (SDRs), i-Medium-chain Dehydrogenases / Reductases (MDRs), kunye ne-Aldo-KetoReductases (AKRs).Imisebenzi ye-catalytic ye-3 iyafana, kodwa isakhiwo kunye neempawu zahluke kakhulu.

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I-imeyile:lchen@syncozymes.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Malunga neKetoreductase:

I-KRED esuka kwi-SyncoZymes: Kukho iintlobo ze-191 zeemveliso ze-enzyme ze-KRED (Inombolo njenge-ES-KRED-101~ES-KRED-291) ephuhliswe yi-SyncoZymes.I-SZ-KRED inokusetyenziswa ngokubanzi kwi-regio- kunye nokunciphisa i-stereoelective ye-aldehydes, i-beta-ketone esters, i-α-ketone esters kunye ne-ketones.

Uhlobo lwe-Catalytic reaction:

Ulwazi ngeMveliso:

Iienzymes	Ikhowudi yeMveliso	Inkcazo
Umgubo we-Enzyme	Umgubo we-Enzyme	isethi ye-187 Ketoreductases, 50 mg nganye 187 izinto * 50mg / into, okanye enye ubungakanani
Ikhithi yokuHlola (SynKit)	ES-KRED-18100	isethi ye-181 Ketoreductases, i-1 mg nganye yezinto ze-181 * 1mg / into

Izinto eziluncedo:

★ Ubucacileyo besubstrate ephezulu.
★ Ukukhetha okuqinileyo kwe-chiral.
★ uguqulo olusebenzayo.
★ Iimveliso ezingaphantsi kweemveliso.
★ Iimeko zokusabela ezithambileyo.
★ Ilungele indalo.

Imiyalelo yokusetyenziswa:

➢ Ukuhlolwa kwe-Enzyme kufuneka kuqhutywe kwi-substrates ezithile ngenxa ye-substrate ekhethekileyo, kwaye ufumane i-enzyme eyenza i-substrate ekujoliswe kuyo kunye neyona nto isebenzayo.
➢ Ungaze udibane neemeko ezigqithisileyo ezinje: ubushushu obuphezulu, i-pH ephezulu/ephantsi kunye ne-organic solvent ene-concentration ephezulu.
➢ Ngokuqhelekileyo, inkqubo yokusabela kufuneka ibandakanye i-substrate, isisombululo se-buffer, i-coenzymes (NAD (H) okanye i-NADP (H)), inkqubo yokuvuselela i-coenzyme (umzekelo, i-glucose kunye ne-glucose dehydrogenase).
➢ I-KRED kufuneka yongezwe okokugqibela kwinkqubo yokusabela, emva kokuba i-pH kunye nobushushu bulungelelaniswe kwimeko yokusabela.
➢ Zonke iintlobo ze-KRED zineemeko ezahlukeneyo zokusabela, ngoko ke nganye kuzo kufuneka ifundwe ngokuzimeleyo.