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I-Nucloside phosphorylse (NP)
Malunga ne-nucleoside phosphorylse
Kukho iintlobo ezi-3 zeemveliso ze-enzyme ze-NP (Inombolo njenge-ES-NP-101~ ES-NP-103) eziphuhliswe yiSyncoZymes. I-ES-NP-101 yi-purine nucleoside phosphorylase, i-ES-NP-102 kunye ne-ES-NP-103 yi-pyrimidine nucleoside phosphorylase. I-Nucleosidephosphorylase inokubola ii-nucleosides zibe ziziseko kunye ne-pentose phosphate. I-Nucleoside phosphorylase inokwahlulwa ibe yi-purine nucleoside phosphorylase kunye ne-pyrimidine nucleoside phosphorylase ngokwendlela ezikhethwa ngayo iisiseko ze-nucleoside. I-purine nucleoside phosphorylase inokugaya i-adenosine ibe yi-adenine, i-inosine ibe yi-hypoxanthine, i-guanosine ibe yi-guanine, kwaye ivelise i-ribose phosphate ngaxeshanye. I-Pyrimidine nucleoside phosphorylase inokugaya i-uridine ibe yi-uracil kwaye ivelise i-ribose phosphate.
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I-Hydroaminase (i-HAM)
Malunga neHydroaminase
Kukho iintlobo ezimbini zemveliso ye-enzyme ye-HAM (Inombolo njenge-ES-HAM-101~ ES-HAM-102) eyenziwe yiSyncoZymes. I-HAM inokwenza i-ammonia ye-enoic acid okanye izinto eziphuma kuyo zivelise i-chiral amino acids. I-HAM ingasetyenziselwa ukwenza i-chiral amino acids (okanye i-chiral amines) kwi-enoic acids (okanye i-alkenes). I-Ammonia donor, efana namanzi e-ammonia okanye ityuwa ye-ammonium, iyimfuneko.
Uhlobo lwempendulo ye-Hydroaminase catalytic
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I-CALB engasebenziyo
I-CALB
I-Recombinant Lipase B evela kwiCandida antarctica (CALB) iveliswa ngokubiliswa okungaphantsi komhlaba ngePichia pastoris eguqulwe ngokwezakhi zofuzo.
I-CALB ingasetyenziswa kwi-water phase okanye kwi-organic phase catalytic esterification, i-esterosis, i-transesterification, i-ring opening polyester synthesis, i-aminolysis, i-hydrolysis ye-amides, i-acylation ye-amines kunye ne-addition reaction.
I-CALB inokukhetha okuphezulu kwe-chiral kunye nokukhetha isikhundla, ngoko ke ingasetyenziswa kakhulu kwimveliso yeoyile, ukutya, amayeza, izinto zokuthambisa kunye nezinye iikhemikhali.
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I-NADH oxidase (NOX)
Malunga ne-NADH oxidase
I-ES-NOX (i-NADH oxidase): I-NOX ibangela i-oxidation ye-NADH ibe yi-NAD+, kwaye iyinxalenye ye-oxidoreductase. Kwinkqubo ye-oxidation, i-O2 iyimfuneko njenge-oxidant, kwaye incitshiswe ibe yi-H2O okanye i-H2O2. Kukho iintlobo ezine zeemveliso ze-NOX enzyme (ES-NOX-101~ES-NOX-104) eziphuhliswe yinkampani yethu, ezinokusetyenziselwa ukuvuselelwa kwe-oxidation ye-coenzyme NAD+.
Uhlobo lwempendulo ye-Catalytic:
or
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I-Phenylalanine ammonia lyase (PAL)
Malunga nePhenylalanine ammonia lyase
I-ES-PAL: Udidi lwee-enzymes ezibangela ukususwa ngokuthe ngqo kwe-L-phenylalanine kwi-transcinnamic acid. I-Syncozymes iphuhlise izinto ezili-10 ze-phenylalanine ammonia lyase (ezibhalwe ngenombolo ye-ES-PAL-101~ES-PAL-110), ezingasetyenziswa ekususweni okanye ekuphenduleni okungasemva kwe-phenylalanine kunye nezinto eziphuma kuyo.
Uhlobo lwempendulo ye-Catalytic:
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I-Catalase (i-CAT)
Malunga neCatalase
I-ES-CAT (iCatalase): ivuselela ukubola kwe-H2O2 ibe yioksijini namanzi. Ifumaneka ikakhulu kwi-mitochondria, kwi-endoplasmic reticulum, kwisibindi sesilwanyana nakwiiseli zegazi ezibomvu, ingakumbi kwisibindi xa sinoxinzelelo oluphezulu, inika umsebenzi wokukhusela umzimba nge-antioxidant. Kwi-biocatalysis, isetyenziswa kakhulu ukususa i-hydrogen peroxide ephuma kwimveliso yokusabela kunye nokunciphisa ukuthintelwa kunye nokungasebenzi kwe-enzyme yi-hydrogen peroxide. Kukho uhlobo olunye kuphela lweemveliso ze-enzyme ze-CAT eziveliswe yiSyncoZymes (Inombolo njenge-ES-CAT).
Uhlobo lwempendulo ye-Catalytic:
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I-Lysine oxidase (LO)
Malunga neLysine oxidase
I-ES-LO (i-Lysine oxidase): ivuselela i-oxidation ye-L-lysine ibe yi-6-amino-2-oxohexanoic acid (okanye i-lactone yayo). Kukho uhlobo olunye kuphela lwemveliso ye-enzyme ye-LO (iNombolo njenge-ES-LO) eyenziwe yiSyncoZymes.
Uhlobo lwempendulo ye-Catalytic:
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I-Phosphokinase (PKase)
Malunga nePhosphokinase
I-ES-PKase (iPhosphokinase): ivuselela ukudluliselwa kwamaqela e-phosphate kwi-ATP ukuya kwezinye iikhompawundi. Ikwavuselela ukudluliselwa kwamaqela e-phosphate kwezinye ii-nucleosides ze-triphosphate ngamanye amaxesha. Uninzi lwee-kinases zifuna ii-ion zesinyithi ezi-divalent ukuze zithathe inxaxheba kwi-reaction (ngokubanzi i-Mg2+). Kukho iintlobo ezingama-21 zeemveliso ze-enzyme ze-PKase (Inombolo njenge-ES-PKase101~ ES-PKase-121) ezenziwe yiSyncoZymes.
Uhlobo lwempendulo ye-Catalytic:
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I-Cyclooxygenase (COX)
Malunga neCyclooxygenase
I-ES-COX (i-Cyclooxygenase): ivuselela ukuguqulwa kweebhondi ze-C=C zibe yi-epoxide. Kukho iintlobo ezili-11 zeemveliso ze-enzyme ze-COX (Inombolo njenge-ES-COX101~ ES-COX-111) eziphuhliswe yiSyncoZymes. Ngokweendlela ezahlukeneyo ze-catalytic, i-COX yeSyncoZymes yahlulwe yaba yi-haloperoxidase kunye ne-styrene monooxygenase. I-ES-COX101, 102, 107-111 ikwi-haloperoxidase, ngelixa i-ES-COX103-106 ikwi-styrene monooxygenase.
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I-Cyclohexanone monooxygenase (CHMO)
Malunga neCyclohexanone monooxygenase
I-ES-CHMO (i-Cyclohexanone monooxygenase): i-Baeyer Villiger monooxygenase (BVMO) ene-cyclohexanone njenge-substrate, inokukhupha i-cyclohexanone ibe yi-cyclohexanol isebenzisa i-oxygen.
Luhlobo lwe-enzyme exhomekeke kwi-flavin. I-flavin e-oxidized incitshiswa ibe yi-flavin ngomjikelo wokunciphisa i-coenzyme II (NADPH) kwi-oxidation elandelayo. Ke ngoko, i-cofactor NADPH iyimfuneko kumjikelo we-flavin. Kukho uhlobo olunye kuphela lwemveliso ye-enzyme ye-CHMO (Inombolo njenge-ES-CHMO101) eyenziwe yiSyncoZymes, enokusetyenziswa uku-oxidation ye-cyclohexanone ibe yi-cyclohexanone.
Uhlobo lwempendulo ye-Catalytic:
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I-Carboxylic acid reductase (CAR)
Malunga neCarboxylic acid reductase
I-ES-CAR (i-Carboxylic acid reductase): ivuselela ukunciphisa iqela le-carboxyl libe liqela le-aldehyde. Kwinkqubo ye-catalytic, ukusebenza kwe-ATP kunye ne-coenzyme NADPH ziyafuneka njengezithuthi ze-hydrogen. Kukho iintlobo ezimbini zeemveliso ze-enzyme ze-CAR (Inombolo njenge-ES-CAR101~ ES-CAR-102) eziphuhliswe yiSyncoZymes.
Uhlobo lwempendulo ye-Catalytic:
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I-Phenylalanine dehydrogenase (PDH)
Malunga nePhenylalanine dehydrogenase
I-ES-PDH: Udidi lwe-oxidoreductase. Impendulo entle inokwenza i-oxidative deamination yetyuwa ye-L phenylalanine xa kukho i-NAD ukuvelisa ityuwa ye-phenylpyruvate, kwaye impendulo echaseneyo ingenza i-synthesis yetyuwa ye-amino acid ehambelanayo kwityuwa ye-phenylpyruvate. I-Syncozymes iphuhlise izinto ezi-8 ze-phenylalanine dehydrogenase (ezibhalwe ngenombolo ye-ES-PDH-101~ES-PDH-108). I-ES-PDH ingasetyenziselwa ukulungisa ityuwa ye-phenylalanine okanye ityuwa ye-amino acid ehambelanayo kwityuwa ye-phenylpyruvic acid okanye izinto eziphuma kuyo.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
