Cyclooxygenase (COX)

Inkcazelo emfutshane:

Malunga neCyclooxygenase

I-ES-COX (i-Cyclooxygenase): ibangela ukuguqulwa kweebhondi ze-C = C kwi-epoxide.Kukho iintlobo ezili-11 zeemveliso ze-enzyme ze-COX (Inombolo njenge-ES-COX101~ ES-COX-111) ephuhliswe yi-SyncoZymes.Ngokweendlela ezahlukeneyo ze-catalytic, i-COX ye-SyncoZymes yahlulwe yaba yi-haloperoxidase kunye ne-styrene monooxygenase.I-ES-COX101, i-102, i-107-111 ye-haloperoxidase, ngelixa i-ES-COX103-106 yeye-styrene monooxygenase.

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I-imeyile:lchen@syncozymes.com

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Iinkcukacha zeMveliso

Iithegi zeMveliso

Malunga neCyclooxygenase:

Uhlobo lwe-Catalytic reaction:

IHaloperoxidase:

I-Styrene monooxygenase:

Ulwazi ngeMveliso:

Iienzymes	Ikhowudi yeMveliso	Inkcazo
Umgubo we-Enzyme	ES-COX-101~ ES-COX-110	isethi ye-10 NADH Cyclooxygenase, 50 mg nganye 10 izinto * 50mg / into, okanye enye ubungakanani

Izinto eziluncedo:

★ Ubucacileyo besubstrate ephezulu.
★ Ukukhetha okuqinileyo kwe-chiral.
★ ukuguqulwa okuphezulu.
★ Iimveliso ezingaphantsi kweemveliso.
★ Iimeko zokusabela ezithambileyo.
★ Ilungele indalo.

Imiyalelo yokusetyenziswa:

➢ Ngokuqhelekileyo, inkqubo ye-haloperoxidase reaction ibandakanya: i-substrate, i-buffer, i-enzyme, i-H2O2 kunye ne-halogen ion.Inkqubo yokusabela ye-Styrene monooxygenase ibandakanya i-substrate, i-buffer, i-enzyme, i-coenzyme kunye nenkqubo yokuvuselela i-coenzyme
➢ I-COX kufuneka yongezwe okokugqibela kwinkqubo yokusabela, emva kokuba i-pH kunye nobushushu bulungelelaniswe kwimeko yokusabela.

Imizekelo yosetyenziso:

Umzekelo 1(Udityaniso lwe-epoxy styrene derivatives ukusuka kwi-styrene derivatives)⁽¹⁾:

Qaphela: imizekelo yesicelo kunye nezikhombisi zenzelwe ukubonisa ububanzi besicelo se-COX ukuze kube lula ukuqonda, kwaye ayihambelani ne-enzyme ethile ye-SyncoZymes.