Umfanekiso oFakiweyo weKetoreductase (KRED)

I-Ketoreductase (KRED)

Inkcazo emfutshane:

Malunga neKetoreductase

Iienzyme: Zii-macromolecular biological catalysts, uninzi lwee-enzyme ziiproteni.

I-Ketoreductase: Ikwabizwa ngokuba yi-“Carbonyl reductase”, zii-enzymes ezivuselela i-reversible redox reaction phakathi kwe-aldehydes/ketones kunye ne-alcohols, kwaye zifuna ii-coenzymes njenge-H transmitter ezifana ne-NADH okanye i-NADPH. Kukho iindidi ezintathu eziphambili ze-KRED: I-Short-chain Dehydrogenase / Reductases (SDRs), i-Medium-chain Dehydrogenases / Reductases (MDRs), kunye ne-Aldo-KetoReductases (AKRs). Imisebenzi ye-catalytic yala mathathu iyafana, kodwa ulwakhiwo kunye neempawu zahlukile kakhulu.

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I-imeyile:lchen@syncozymes.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Malunga neKetoreductase:

I-KRED evela kwiSyncoZymes: Kukho iintlobo ezili-191 zeemveliso ze-enzyme ze-KRED (Inombolo njenge-ES-KRED-101~ES-KRED-291) ezenziwe yiSyncoZymes. I-SZ-KRED ingasetyenziswa kakhulu ekunciphiseni i-aldehydes, ii-ester ze-beta-ketone, ii-ester ze-α-ketone kunye nee-ketones ngokwengingqi nangokwe-stereoselective.

Uhlobo lwempendulo ye-Catalytic:

Ulwazi lweMveliso:

Iienzymes	Ikhowudi yeMveliso	Inkcazo
Umgubo we-Enzyme	Umgubo we-Enzyme	iseti yeeKetoreductases ezili-187, 50 mg nganye, izinto ezili-187 * 50mg / into, okanye olunye ubungakanani
Isixhobo sokuvavanya (iSynKit)	ES-KRED-18100	iseti yeeKetoreductases ezili-181, 1 mg nganye Izinto ezili-181 * 1mg / into

Iingenelo:

★ Ukucaciswa okuphezulu kwe-substrate.
★ Ukukhetha okunamandla kwe-chiral.
★ Ukusebenza kakuhle kokuguqula.
★ Iimveliso ezingaphantsi kwezinye.
★ Iimeko zokusabela okuncinci.
★ Inobuhlobo nokusingqongileyo.

Imiyalelo yokusebenzisa:

➢ Ukuhlolwa kwee-enzyme kufuneka kwenziwe kwiindawo ezithile ngenxa yobungakanani be-substrate, kwaye kufunyanwe i-enzyme evuselela i-substrate ekujoliswe kuyo enefuthe elihle kakhulu le-catalytic.
➢ Ungaze udibane neemeko ezinzima ezifana nobushushu obuphezulu, i-pH ephezulu/ephantsi kunye nesinyibilikisi sendalo esinoxinzelelo oluphezulu.
➢ Ngokwesiqhelo, inkqubo yokusabela kufuneka iquke i-substrate, isisombululo se-buffer, ii-coenzymes (NAD(H) okanye i-NADP(H)), inkqubo yokuvuselela i-coenzyme (umz. i-glucose kunye ne-glucose dehydrogenase).
➢ I-KRED kufuneka yongezwe okokugqibela kwinkqubo yokusabela, emva kokuba i-pH kunye nobushushu zilungisiwe kwimeko yokusabela.
➢ Zonke iintlobo ze-KRED zineemeko ezahlukeneyo zokusabela ezifanelekileyo, ngoko ke nganye yazo kufuneka ifundwe ngakumbi nganye nganye.