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I-Imine reductase (IRED)
Malunga ne-Imine reductase
I-ES-IRED: Ludidi lwee-enzymes ezikhuthaza ukunciphisa i-C=N bond kwi-CN bond. Yeye-redox enzyme, ene-coenzyme NADPH yokuthutha i-hydrogen. Ngokwendlela ezithandwa ngayo iimveliso ze-chiral, zinokwahlulwa zibe yi-R-IRED kunye ne-S-IRED. I-Syncozymes yenze i-15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), ezingasetyenziswa kakhulu ekunciphiseni i-regioselective kunye ne-stereoselective ye-imines ukulungiselela i-chiral amines.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
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I-Nitrile reductase (NRED)
Malunga ne-Nitrile reductase
Kukho iintlobo ezintathu zemveliso ye-enzyme ye-NRED (Inombolo njenge-ES-NRED101~ ES-NRED103) eyenziwe yiSyncoZymes. I-NRED inokwenza i-catalyst inciphise iqela le-nitrile ibe yi-amine. Kwinkqubo ye-catalysis, i-NADPH iyadingeka njengomthuthi we-hydrogen.
Uhlobo lokusabela lwe-Nitrile reductasecatalytic
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I-imeyile:lchen@syncozymes.com
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I-Leucine Dehydrogenase (LeuDH)
Malunga neLeucine dehydrogenase
Kukho uhlobo olunye lwemveliso ye-enzyme yeLeuDH (Inombolo njenge-ES-LeuDH-101) eyenziwe yiSyncoZymes. I-LeuDH inokwenza i-ammoniation ye-4-methylbutanoic acid (ityuwa) ibe yi-L-leucine okanye i-oxidation ye-leucine ibe yi-4-methylbutanoic acid. I-ES-LeuDH ingenza i-α-keto acids ibe yi-reductive amination enesakhiwo esifanayo ukulungiselela i-amino acid derivatives ehambelanayo. Kwinkqubo ye-catalysis, i-NADH iyimfuneko njengomthuthi we-hydrogen.
Uhlobo lwempendulo ye-Leucine dehydrogenasecatalytic
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I-imeyile:lchen@syncozymes.com
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I-Threonine deaminase (TDA)
Malunga neThreonine deaminase
I-ES-TDA (iThreonine deaminase): iproteni ye-pyridoxal phosphate evuselela ukususwa kwe-threonine ukuze kuveliswe i-2-ketobutyric acid kunye ne-ammonia. I-Pyridoxal 5-phosphate iyimfuneko njenge-coenzyme kwinkqubo ye-catalytic. Kukho uhlobo olunye kuphela lwemveliso ye-enzyme ye-TDA (iNombolo njenge-ES-TDA) eyenziwe yiSyncoZymes, enokusetyenziswa ukulungiselela i-2-ketobutyric acid okanye izinto eziphuma kuyo kwi-threonine.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
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I-Amine Dehydrogenase (AmDH)
Malunga ne-Amine Dehydrogenase
I-ES-AmDH (i-Amine Dehydrogenase): i-enzyme enokushukumisa i-ammoniation yeqela le-carbonyl ize iyinciphise ibe liqela le-amino. Yi-enzyme exhomekeke kwi-coenzyme NADH, kwaye i-NADH isebenza njengomthumeli we-hydrogen. Kukho iintlobo ezine zeemveliso ze-enzyme ze-AmDH (Inombolo njenge-ES-AmDH101 ~ ES-AmDH104) eyenziwe yiSyncoZymes, engasetyenziswa kwi-regioselective okanye stereoselective reductive amination ye-aldehydes kunye neeketones.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
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I-Nucloside phosphorylse (NP)
Malunga ne-nucleoside phosphorylse
Kukho iintlobo ezi-3 zeemveliso ze-enzyme ze-NP (Inombolo njenge-ES-NP-101~ ES-NP-103) eziphuhliswe yiSyncoZymes. I-ES-NP-101 yi-purine nucleoside phosphorylase, i-ES-NP-102 kunye ne-ES-NP-103 yi-pyrimidine nucleoside phosphorylase. I-Nucleosidephosphorylase inokubola ii-nucleosides zibe ziziseko kunye ne-pentose phosphate. I-Nucleoside phosphorylase inokwahlulwa ibe yi-purine nucleoside phosphorylase kunye ne-pyrimidine nucleoside phosphorylase ngokwendlela ezikhethwa ngayo iisiseko ze-nucleoside. I-purine nucleoside phosphorylase inokugaya i-adenosine ibe yi-adenine, i-inosine ibe yi-hypoxanthine, i-guanosine ibe yi-guanine, kwaye ivelise i-ribose phosphate ngaxeshanye. I-Pyrimidine nucleoside phosphorylase inokugaya i-uridine ibe yi-uracil kwaye ivelise i-ribose phosphate.
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I-imeyile:lchen@syncozymes.com
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I-Hydroaminase (i-HAM)
Malunga neHydroaminase
Kukho iintlobo ezimbini zemveliso ye-enzyme ye-HAM (Inombolo njenge-ES-HAM-101~ ES-HAM-102) eyenziwe yiSyncoZymes. I-HAM inokwenza i-ammonia ye-enoic acid okanye izinto eziphuma kuyo zivelise i-chiral amino acids. I-HAM ingasetyenziselwa ukwenza i-chiral amino acids (okanye i-chiral amines) kwi-enoic acids (okanye i-alkenes). I-Ammonia donor, efana namanzi e-ammonia okanye ityuwa ye-ammonium, iyimfuneko.
Uhlobo lwempendulo ye-Hydroaminase catalytic
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I-imeyile:lchen@syncozymes.com
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I-CALB engasebenziyo
I-CALB
I-Recombinant Lipase B evela kwiCandida antarctica (CALB) iveliswa ngokubiliswa okungaphantsi komhlaba ngePichia pastoris eguqulwe ngokwezakhi zofuzo.
I-CALB ingasetyenziswa kwi-water phase okanye kwi-organic phase catalytic esterification, i-esterosis, i-transesterification, i-ring opening polyester synthesis, i-aminolysis, i-hydrolysis ye-amides, i-acylation ye-amines kunye ne-addition reaction.
I-CALB inokukhetha okuphezulu kwe-chiral kunye nokukhetha isikhundla, ngoko ke ingasetyenziswa kakhulu kwimveliso yeoyile, ukutya, amayeza, izinto zokuthambisa kunye nezinye iikhemikhali.
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I-NADH oxidase (NOX)
Malunga ne-NADH oxidase
I-ES-NOX (i-NADH oxidase): I-NOX ibangela i-oxidation ye-NADH ibe yi-NAD+, kwaye iyinxalenye ye-oxidoreductase. Kwinkqubo ye-oxidation, i-O2 iyimfuneko njenge-oxidant, kwaye incitshiswe ibe yi-H2O okanye i-H2O2. Kukho iintlobo ezine zeemveliso ze-NOX enzyme (ES-NOX-101~ES-NOX-104) eziphuhliswe yinkampani yethu, ezinokusetyenziselwa ukuvuselelwa kwe-oxidation ye-coenzyme NAD+.
Uhlobo lwempendulo ye-Catalytic:
or
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I-Phenylalanine ammonia lyase (PAL)
Malunga nePhenylalanine ammonia lyase
I-ES-PAL: Udidi lwee-enzymes ezibangela ukususwa ngokuthe ngqo kwe-L-phenylalanine kwi-transcinnamic acid. I-Syncozymes iphuhlise izinto ezili-10 ze-phenylalanine ammonia lyase (ezibhalwe ngenombolo ye-ES-PAL-101~ES-PAL-110), ezingasetyenziswa ekususweni okanye ekuphenduleni okungasemva kwe-phenylalanine kunye nezinto eziphuma kuyo.
Uhlobo lwempendulo ye-Catalytic:
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I-Catalase (i-CAT)
Malunga neCatalase
I-ES-CAT (iCatalase): ivuselela ukubola kwe-H2O2 ibe yioksijini namanzi. Ifumaneka ikakhulu kwi-mitochondria, kwi-endoplasmic reticulum, kwisibindi sesilwanyana nakwiiseli zegazi ezibomvu, ingakumbi kwisibindi xa sinoxinzelelo oluphezulu, inika umsebenzi wokukhusela umzimba nge-antioxidant. Kwi-biocatalysis, isetyenziswa kakhulu ukususa i-hydrogen peroxide ephuma kwimveliso yokusabela kunye nokunciphisa ukuthintelwa kunye nokungasebenzi kwe-enzyme yi-hydrogen peroxide. Kukho uhlobo olunye kuphela lweemveliso ze-enzyme ze-CAT eziveliswe yiSyncoZymes (Inombolo njenge-ES-CAT).
Uhlobo lwempendulo ye-Catalytic:
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I-Lysine oxidase (LO)
Malunga neLysine oxidase
I-ES-LO (i-Lysine oxidase): ivuselela i-oxidation ye-L-lysine ibe yi-6-amino-2-oxohexanoic acid (okanye i-lactone yayo). Kukho uhlobo olunye kuphela lwemveliso ye-enzyme ye-LO (iNombolo njenge-ES-LO) eyenziwe yiSyncoZymes.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
