Abavelisi beemveliso - Imveliso yeemveliso zaseTshayina kunye nababoneleli

I-Phosphokinase (PKase)

Malunga nePhosphokinase

I-ES-PKase (iPhosphokinase): ivuselela ukudluliselwa kwamaqela e-phosphate kwi-ATP ukuya kwezinye iikhompawundi. Ikwavuselela ukudluliselwa kwamaqela e-phosphate kwezinye ii-nucleosides ze-triphosphate ngamanye amaxesha. Uninzi lwee-kinases zifuna ii-ion zesinyithi ezi-divalent ukuze zithathe inxaxheba kwi-reaction (ngokubanzi i-Mg2+). Kukho iintlobo ezingama-21 zeemveliso ze-enzyme ze-PKase (Inombolo njenge-ES-PKase101~ ES-PKase-121) ezenziwe yiSyncoZymes.
Uhlobo lwempendulo ye-Catalytic:

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I-imeyile:lchen@syncozymes.com

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I-Cyclooxygenase (COX)

Malunga neCyclooxygenase

I-ES-COX (i-Cyclooxygenase): ivuselela ukuguqulwa kweebhondi ze-C=C zibe yi-epoxide. Kukho iintlobo ezili-11 zeemveliso ze-enzyme ze-COX (Inombolo njenge-ES-COX101~ ES-COX-111) eziphuhliswe yiSyncoZymes. Ngokweendlela ezahlukeneyo ze-catalytic, i-COX yeSyncoZymes yahlulwe yaba yi-haloperoxidase kunye ne-styrene monooxygenase. I-ES-COX101, 102, 107-111 ikwi-haloperoxidase, ngelixa i-ES-COX103-106 ikwi-styrene monooxygenase.

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Cyclohexanone monooxygenase (CHMO)

Malunga neCyclohexanone monooxygenase

I-ES-CHMO (i-Cyclohexanone monooxygenase): i-Baeyer Villiger monooxygenase (BVMO) ene-cyclohexanone njenge-substrate, inokukhupha i-cyclohexanone ibe yi-cyclohexanol isebenzisa i-oxygen.

Luhlobo lwe-enzyme exhomekeke kwi-flavin. I-flavin e-oxidized incitshiswa ibe yi-flavin ngomjikelo wokunciphisa i-coenzyme II (NADPH) kwi-oxidation elandelayo. Ke ngoko, i-cofactor NADPH iyimfuneko kumjikelo we-flavin. Kukho uhlobo olunye kuphela lwemveliso ye-enzyme ye-CHMO (Inombolo njenge-ES-CHMO101) eyenziwe yiSyncoZymes, enokusetyenziswa uku-oxidation ye-cyclohexanone ibe yi-cyclohexanone.

Uhlobo lwempendulo ye-Catalytic:

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Carboxylic acid reductase (CAR)

Malunga neCarboxylic acid reductase

I-ES-CAR (i-Carboxylic acid reductase): ivuselela ukunciphisa iqela le-carboxyl libe liqela le-aldehyde. Kwinkqubo ye-catalytic, ukusebenza kwe-ATP kunye ne-coenzyme NADPH ziyafuneka njengezithuthi ze-hydrogen. Kukho iintlobo ezimbini zeemveliso ze-enzyme ze-CAR (Inombolo njenge-ES-CAR101~ ES-CAR-102) eziphuhliswe yiSyncoZymes.

Uhlobo lwempendulo ye-Catalytic:

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Eluxadoline Intermediate methyl 5-(((S)-2-((tert-butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)-N-((S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl)propanamido)methyl)-2-methoxybenzoate

Inombolo yeKhathalogu. SZ-2078

I-CAS: 1137026-67-5

Ubumsulwa: 99%

Ukusetyenziswa kwe-Eluxadoline

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Eluxadoline Intermediate (S)-Methyl 2-Methoxy-5-((1-(4-phenyl-1H-imidazol-2-yl)ethylamino)methyl)benzoate

Inombolo yeKhathalogu. SZ-2077

I-CAS: 1391712-57-4

Ubumsulwa: 99%

Ukusetyenziswa kwe-Eluxadoline

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Adapalene Intermediate 1-(5-bromo-2-methoxy-phenyl)adamantane

Inombolo yeKhathalogu. SZ-1559

I-CAS: 104224-63-7

Ubumsulwa: 99%

Ukusetyenziswa kwe-Adpalene

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Eluxadoline Intermediate (S)-Methyl 2-Methoxy-5-((1-(4-phenyl-1H-imidazol-2-yl)ethylamino)methyl)benzoate i-oxalic acid

Inombolo yeKhathalogu. SZ-2077

I-CAS: 2046303-09-5

Ubumsulwa: 99%

Ukusetyenziswa kwe-Eluxadoline

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Ibrutinib Intermediate (S)-1-Boc-3-hydroxypiperidine

Inombolo yeKhathalogu. SZ-1527

I-CAS: 143900-44-1

Ubumsulwa: 99%

Ukusetyenziswa kwe-Ibrutinib

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Ibrutinib ePhakathi 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Inombolo yeKhathalogu. SZ-2028

I-CAS: 330786-24-8

Ubumsulwa: 99%

Ukusetyenziswa kwe-Ibrutinib

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Ibrutinib Intermediate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Inombolo yeKhathalogu. SZ-2028-4

I-CAS: 330792-70-6

Ubumsulwa: 99%

Ukusetyenziswa: 25kg/umphanda

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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I-Phenylalanine dehydrogenase (PDH)

Malunga nePhenylalanine dehydrogenase

I-ES-PDH: Udidi lwe-oxidoreductase. Impendulo entle inokwenza i-oxidative deamination yetyuwa ye-L phenylalanine xa kukho i-NAD ukuvelisa ityuwa ye-phenylpyruvate, kwaye impendulo echaseneyo ingenza i-synthesis yetyuwa ye-amino acid ehambelanayo kwityuwa ye-phenylpyruvate. I-Syncozymes iphuhlise izinto ezi-8 ze-phenylalanine dehydrogenase (ezibhalwe ngenombolo ye-ES-PDH-101~ES-PDH-108). I-ES-PDH ingasetyenziselwa ukulungisa ityuwa ye-phenylalanine okanye ityuwa ye-amino acid ehambelanayo kwityuwa ye-phenylpyruvic acid okanye izinto eziphuma kuyo.
Uhlobo lwempendulo ye-Catalytic:

Iselfowuni/iWechat/iWhatsApp: +86-13681683526

I-imeyile:lchen@syncozymes.com

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