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IiOxynitrilases (HNL)
Malunga ne-oxynitrilases
Ii-ES-HNL: Yi-enzyme yodidi ekhetha ukongezwa kwe-HCN kwi-aldehydes (ii-ketones) ukuze kufunyanwe i-R okanye i-S type cyanide alcohols, enokuguqulwa ngokulula ibe ziintlobo ezininzi zamayeza okanye iziyobisi ngokusebenzisa indlela yeekhemikhali.
Kukho iintlobo ezingama-29 zeemveliso ze-oxynitrilase (Inombolo njenge-ES-HNL-101～ES-HNL-129) eziphuhliswe yiSyncoZymes. I-SZ-HNL sisixhobo esiluncedo sokudibanisa i-(R)-cyanohydrins okanye (S)-cyanohydrins ngokweengingqi kunye nokukhetha i-stereo-selective kwiindidi ezahlukeneyo ze-aldehydes ezinuka kamnandi, i-aliphatic kunye ne-heterocyclic okanye ii-ketones.
Uhlobo lwempendulo ye-Catalytic:
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I-Nitro reductase (NTR)
Malunga ne-nitro reductase
Ii-ES-NTR: Zii-flavoenzymes ezibangela ukunciphisa amaqela e-nitro ngokuxhomekeke kwi-NAD(P)H kwiikhompawundi ze-nitroaromatic kunye ne-nitroheterocyclic ukuya kwi-hydroxylamino kunye/okanye i-amino derivatives. Zisetyenziswa kakhulu kwi-organic synthesis ye-aromatic hydroxylamine kunye ne-aromatic amine, unyango lwe-tumor, ukufunyanwa kwezinto eziphilayo kunye nokuwohloka kokungcola kwendalo. Kukho iintlobo ezili-12 zeemveliso zeNitro reductase (NTR) (Inombolo njenge-ES-NTR-101~ES-NTR-112) ezenziwe yiSyncoZymes.
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I-Aldolase (i-DERA)
I-ES-DERA: Ingavuselela ngempumelelo ukongezwa kwee-ketones ze-donor kwi-receptor aldehydes. Ngaphezu koko, impendulo ingenziwa kwisisombululo samanzi se-pH engathathi hlangothi ngaphandle kwamanyathelo akhethekileyo okukhusela. Zikwi-aldolase yeklasi I, eyenza isiseko seShiff kwinkqubo ye-catalytic. I-substrate idityaniswe ngokudibeneyo neqela le-amino lendawo esebenzayo ukuqala ukwaphuka nokwakheka kwe-bond. Umahluko phakathi kwe-DERAs kunye nezinye i-aldolases kukuba i-substrates abazivuselelayo zi-aldehydes kwaye zinokuqhubeka nokufuma kwe-aldehydes.
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I-cytochrome P450 monooxygenase (CYP)
Malunga ne-CYP
I-ES-CYPs: Ludidi lwee-enzymes ze-redox ezine-mercaptan-heme njengeziko elisebenzayo lokuguqula ukuhanjiswa kweoksijini. Zii-oxygenases zesiphelo kwaye zifuna i-heme ukuze isebenze ioksijini.
I-Cytochrome P450 monooxygenase ivuselela i-oxidation, i-epoxidation kunye ne-hydroxylation ye-alkyl, i-hydroxylation kunye ne-oxidation ye-ammonia, i-oxidation ye-sulfur, i-dealkylation (i-oxygen, i-sulfur, i-ammonia), i-oxidative dehydrogenation, i-deamination kunye ne-dehalogenation.
Kukho iintlobo ezisi-8 zeemveliso ze-cytochrome P450 monooxygenase (Inombolo njenge-ES-CYP-101～ES-CYP-108) ezenziwe yiSyncoZymes.Iselfowuni/iWechat/iWhatsApp: +86-13681683526
I-imeyile:lchen@syncozymes.com
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I-oxidase yotywala (AOX)
Malunga ne-oxidase yotywala
Ii-ES-AOX: Ezi enzymes ziyakwazi ukushukumisa i-oxidation ye-fatty alcohols okanye i-aryl-alcohols ukuze zenze i-aldehydes. Zisebenzisa i-molecule oxygen kodwa azifuni i-cofactor eyongeziweyo ngaphandle, kunye ne-hydrogen peroxide eveliswayo.
Kukho iintlobo ezi-6 zeemveliso ze-alcohol oxidases (Inombolo njenge-ES-AOX-101~ES-AOX-106) eziphuhliswe yiSyncoZymes. I-ES-AOX101 kunye ne-ES-AOX102 zikhetha ii-substrates ze-aliphatic alcohol, i-ES-AOX103~ ES-AOX105 zikhetha ii-substrates ze-alcohol ezinuka kamnandi, kwaye i-ES-AOX106 yi-cholesterol oxidase. I-SZ-AOX sisixhobo esiluncedo sokubangela i-oxidation yee-fatty alcohols okanye ii-aryl-alcohols ukuvelisa i-aldehydes.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
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I-D-Amino acid dehydrogenase (D-AADH)
Malunga ne-D-Amino acid dehydrogenase
I-ES-D-AADH (i-D-Amino acid dehydrogenase): i-enzyme enokunciphisa i-2-keto acid ibe yi-D-amino acid ehambelanayo. I-reaction ifuna i-NADP(H) kunye ne-inorganic ammonia donor (efana ne-ammonia okanye i-ammonium ion). Kukho iintlobo ezili-17 ze-D-amino acid dehydrogenases (Inombolo njenge-ES-DAADH-101~ ES-DAADH-117) eyenziwe yiSyncoZymes.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
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I-Esterase kunye neLipase (PLE kunye neCALB)
Malunga ne-Esterase kunye neLipase
Ii-ES-PLE: Udidi lwee-hydrolases ezikhuthaza ukwakheka nokuqhekeka kwee-ester bonds. Zingathatha inxaxheba kwiintlobo ezininzi zeempendulo ze-biochemical, ezifana ne-esterification, i-transesterification kunye ne-hydrolysis. Zisetyenziswa kakhulu kwiindawo ezininzi ezifana nokulungiswa kokutya, ishishini leekhemikhali, i-biomedicine, amayeza e-chiral kunye nonyango lokusingqongileyo.
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I-Epoxide hydrolase (EH)
Malunga ne-epoxide hydrolase
I-EH yi-ether hydrolase evuselela i-stereoselective hydrolysis yee-racemic epoxides ukuvelisa i-1, 2-diol kunye nee-epoxides ezisebenzayo, ezinokusetyenziselwa isisombululo se-chiral seepoxides okanye ukulungiswa kwee-chiral diols. Zisetyenziswa kakhulu kwezonyango nakwamanye amasimi. Kukho iintlobo ezi-3 zeemveliso ze-epoxide hydrolases (Inombolo njenge-ES-EH-101～ES-EH-103) eziphuhliswe yiSyncoZymes. I-ES-EH sisixhobo esiluncedo sokuvuselela ukwenziwa kwee-chiral alcohols ngokusebenzisa i-stereoselective hydrolysis yee-aliphatic kunye nee-aromatic epoxides.
Uhlobo lwempendulo ye-Catalytic:
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I-formate dehydrogenase (FDH)
Malunga neFormate dehydrogenase
I-ES-FDH (i-Formate dehydrogenase): I-FDH ikhuthaza ukususwa kwe-hydrogenation ye-ammonium formate ukuze ivelise i-carbon dioxide kunye ne-ammonia, kwaye inciphise i-NAD ibe yi-NADH nge-NAD njenge-electron receptor. I-FDH idla ngokusetyenziselwa ukuvuselelwa kwe-coenzyme NADH. Kukho iintlobo ezine zeemveliso ze-enzyme ze-FDH (ES-FDH-101~ES-FDH-104) ezenziwe yiSyncoZymes, phakathi kwazo i-ES-FDH102 inomsebenzi ophezulu kwaye yeyona FDH icetyiswayo kakhulu.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
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I-glucose dehydrogenase (GDH)
Malunga neGlucose dehydrogenase
I-ES-GDH (i-glucose dehydrogenase): I-GDH ivuselela ukususwa kwe-glucose ukuze ivelise i-gluconic acid (i-lactone), kwaye inciphise i-NAD(P)+ ibe yi-NAD(P)H, kunye ne-NAD(P)+ njenge-electron receptor. I-GDH idla ngokusetyenziselwa ukuvuselelwa kwe-coenzyme NAD(P)H kwiindawo ze-biocatalysis kunye nezinye ii-enzyme eziphambili. Kukho iintlobo ezili-10 zeemveliso ze-enzyme ze-GDH (ES-GDH-101~ES-GDH-110) ezenziwe yiSyncoZymes, phakathi kwazo i-ES-GDH110 inomsebenzi ophezulu kwaye yeyona GDH icetyiswayo kakhulu.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
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I-Monoamine oxidase (MAO)
Malunga neMonoamine oxidase
I-ES-MAO (i-Monoamine oxidase): I-MAO ivuselela i-oxidative deamination ye-monoamines ukuvelisa i-hydrogen peroxide, i-ammonia kunye ne-aldehydes ehambelanayo. Kwinkqubo ye-catalytic, i-oksijini iyimfuneko njenge-oxidant. Kukho iintlobo ezi-6 zeemveliso ze-enzyme ze-MAO (Inombolo njenge-ES-MAO-101 ~ ES-MAO-106) eziphuhliswe yiSyncoZymes, ezinokusetyenziswa kwi-oxidative deamination ye-monoamine compounds.
Uhlobo lwempendulo ye-Catalytic:
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I-imeyile:lchen@syncozymes.com
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I-Lactate Dehydrogenase (LDH)
Malunga neLactate dehydrogenase
Kukho uhlobo olunye lwemveliso ye-enzyme ye-LDH (iNombolo njenge-ES-LDH) eyenziwe yiSyncoZymes. I-LDH inokwenza i-pyruvate inciphe ibe yi-L-lactic acid, okanye inciphe nezinye ii-α-keto acids ezifanayo. Kwinkqubo ye-catalysis, i-NADH iyimfuneko njengomthuthi we-hydrogen.
Uhlobo lokusabela kwe-lactate dehydrogenasecatalytic
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I-imeyile:lchen@syncozymes.com
