Umfanekiso obonisiweyo weCyclooxygenase (COX)

I-Cyclooxygenase (COX)

Inkcazo emfutshane:

Malunga neCyclooxygenase

I-ES-COX (i-Cyclooxygenase): ivuselela ukuguqulwa kweebhondi ze-C=C zibe yi-epoxide. Kukho iintlobo ezili-11 zeemveliso ze-enzyme ze-COX (Inombolo njenge-ES-COX101~ ES-COX-111) eziphuhliswe yiSyncoZymes. Ngokweendlela ezahlukeneyo ze-catalytic, i-COX yeSyncoZymes yahlulwe yaba yi-haloperoxidase kunye ne-styrene monooxygenase. I-ES-COX101, 102, 107-111 ikwi-haloperoxidase, ngelixa i-ES-COX103-106 ikwi-styrene monooxygenase.

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I-imeyile:lchen@syncozymes.com

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Malunga neCyclooxygenase:

Uhlobo lwempendulo ye-Catalytic:

I-Haloperoxidase:

I-Styrene monooxygenase:

Ulwazi lweMveliso:

Iienzymes	Ikhowudi yeMveliso	Inkcazo
Umgubo we-Enzyme	ES-COX-101~ ES-COX-110	iseti ye-10 NADH Cyclooxygenase, 50 mg nganye Izinto ezili-10 * 50mg / into, okanye olunye ubungakanani

Iingenelo:

★ Ukucaciswa okuphezulu kwe-substrate.
★ Ukukhetha okunamandla kwe-chiral.
★ Uguquko oluphezulu.
★ Iimveliso ezingaphantsi kwezinye.
★ Iimeko zokusabela okuncinci.
★ Inobuhlobo nokusingqongileyo.

Imiyalelo yokusebenzisa:

➢ Ngokwesiqhelo, inkqubo yokusabela ye-haloperoxidase ibandakanya: i-substrate, i-buffer, i-enzyme, i-H2O2 kunye ne-halogen ion. Inkqubo yokusabela ye-styrene monooxygenase ibandakanya i-substrate, i-buffer, i-enzyme, i-coenzyme kunye nenkqubo yokuvuselela i-coenzyme
➢ I-COX kufuneka yongezwe okokugqibela kwinkqubo yokusabela, emva kokuba i-pH kunye nobushushu zilungisiwe kwimeko yokusabela.

Imizekelo yoSetyenziso:

Umzekelo 1 (Ukwenziwa kwezinto eziphuma kwi-epoxy styrene derivatives ezivela kwi-styrene derivatives)⁽¹⁾:

Qaphela: imizekelo yesicelo kunye neereferensi zenzelwe ukubonisa ububanzi besicelo se-COX ukuze kube lula ukuyiqonda, kwaye azihambelani ne-enzyme ethile yeSyncoZymes.